CphA beta-lactamase [AMR Gene Family]

Accession ARO:3000581
DefinitionCphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein.
Drug Classcarbapenem
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ subclass B2 (metallo-) beta-lactamase
Sub-Term(s)
9 ontology terms | Show
Publications

Lienard BM, et al. 2008. Org Biomol Chem 6(13): 2282-2294. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (PMID 18563261)