cphA5

Accession ARO:3003101
DefinitioncphA5 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas salmonicida. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein.
AMR Gene FamilyCphA beta-lactamase
Drug Classcarbapenem
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ CphA beta-lactamase [AMR Gene Family]
Resistomes

Prevalence of cphA5 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 85 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 450


>gb|AAP69913.1|+|cphA5 [Aeromonas salmonicida]
MMKGWIKCGLAGAVVLVASFWGGSVHAAAISLTQVSGPVYVVEDNYYVKENSMVYFGAKGVTIVGATWTPDTARELHKLIKRVNNKPVLE
VINTNYHTGQAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFNLQEGKVRAFYAGPAHTPDGIF
VYFPDQQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKIVVGGHDSPLHGPELIDHYQALIKAATHS


>gb|AY227051|+|1-765|cphA5 [Aeromonas salmonicida]
ATGATGAAAGGTTGGATAAAGTGCGGGCTGGCCGGAGCTGTGGTGCTGGTGGCGAGTTTCTGGGGCGGCAGCGTGCATGCGGCGGCGATC
TCCCTCACTCAGGTAAGCGGCCCTGTCTATGTGGTGGAGGATAACTACTACGTCAAAGAGAACTCCATGGTTTATTTCGGAGCCAAGGGA
GTGACGATAGTGGGGGCGACCTGGACGCCGGATACCGCCCGCGAGCTGCACAAGCTGATCAAACGGGTCAACAACAAGCCTGTGCTGGAG
GTGATCAACACCAACTACCACACCGGACAGGCAGGGGGTAACGCCTACTGGAAGTCCATCGGTGCCAAGGTGGTCTCGACCCGCCAGACC
CGGGATCTGATGAAGAGCGACTGGGCCGAGATCGTCGCCTTTACCCGCAAGGGGCTGCCGGAGTACCCGGACTTGCCGCTGGTGCTGCCG
AACGTGGTGCACGATGGTGACTTCAATCTGCAAGAGGGCAAGGTGCGCGCCTTCTATGCGGGCCCGGCCCACACGCCGGACGGCATCTTT
GTCTACTTCCCTGACCAGCAGGTGCTCTATGGCAACTGCATCCTCAAGGAGAAGCTGGGCAACCTGAGCTTTGCCGATGTGAAGGCGTAT
CCGCAGACGCTGGAGCGGCTGAAAGCGATGAAGCTGCCCATCAAGATTGTGGTTGGCGGTCACGACTCGCCGCTGCACGGCCCCGAGTTG
ATTGATCACTACCAGGCGCTGATCAAGGCCGCTACTCACTCATAA