THIN-B beta-lactamase [AMR Gene Family]

Accession ARO:3004214
DefinitionBeta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems.
Drug Classcarbapenem, penam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ subclass B3 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
1 ontology terms | Show

Docquier JD, et al. 2004. Antimicrob Agents Chemother 48(12): 4778-4783. Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum. (PMID 15561856)

Rossolini GM, et al. 2001. Antimicrob Agents Chemother 45(3): 837-844. Metallo-beta-lactamase producers in environmental microbiota: new molecular class B enzyme in Janthinobacterium lividum. (PMID 11181369)