| Accession | ARO:3004214 |
| Definition | Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. |
| Drug Class | carbapenem, cephalosporin, penam |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactam antibiotic + beta-lactamase + cephem + class B (metallo-) beta-lactamase |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_drug_class carbapenem [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + subclass B3 (metallo-) beta-lactamase |
| Sub-Term(s) | 1 ontology terms | Show + THIN-B |
| Publications | Docquier JD, et al. 2004. Antimicrob Agents Chemother 48(12): 4778-4783. Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum. (PMID 15561856) Rossolini GM, et al. 2001. Antimicrob Agents Chemother 45(3): 837-844. Metallo-beta-lactamase producers in environmental microbiota: new molecular class B enzyme in Janthinobacterium lividum. (PMID 11181369) |