Accession | ARO:3004570 |
Definition | PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins. |
Drug Class | carbapenem, cephalosporin, penam |
Resistance Mechanism | antibiotic inactivation |
Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactam antibiotic + beta-lactamase + cephem + class B (metallo-) beta-lactamase |
Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_drug_class carbapenem [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + subclass B3 (metallo-) beta-lactamase |
Sub-Term(s) | 1 ontology terms | Show + PNGM-1 |
Publications | Park KS, et al. 2018. J Glob Antimicrob Resist 14:302-305 PNGM-1, a novel subclass B3 metallo-β-lactamase from a deep-sea sediment metagenome. (PMID 29842976) |