PNGM beta-lactamase [AMR Gene Family]

Accession ARO:3004570
DefinitionPNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins.
Drug Classcarbapenem, cephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification13 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ subclass B3 (metallo-) beta-lactamase
Sub-Term(s)
1 ontology terms | Show
Publications

Park KS, et al. 2018. J Glob Antimicrob Resist 14:302-305 PNGM-1, a novel subclass B3 metallo-β-lactamase from a deep-sea sediment metagenome. (PMID 29842976)