PNGM-1

Accession ARO:3004571
CARD Short NamePNGM-1
DefinitionPNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era.
AMR Gene FamilyPNGM beta-lactamase
Drug Classpenam, cephalosporin, carbapenem
Resistance Mechanismantibiotic inactivation
Classification16 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ PNGM beta-lactamase [AMR Gene Family]
Publications

Park KS, et al. 2018. J Glob Antimicrob Resist 14:302-305 PNGM-1, a novel subclass B3 metallo-β-lactamase from a deep-sea sediment metagenome. (PMID 29842976)

Resistomes

Prevalence of PNGM-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AWN09461.1|+|PNGM-1 [uncultured bacterium]
MAGGKVTSSTGIAPKRYVYYPGSEELGPDEIRVIACGTGMPTARRAQAAAAWVVELGNGDKFIVDIGSGSMANIQSLMIPANYLTKIFLT
HLHTDHWGDLVSMWAGGWTAGRTDPLEVWGPSGSREDMGTKYAVEHMLKAYNWDYMTRAVTINPRPGDINVHEFDYRALNEVVYQENGVT
FRSWPCIHAGDGPVSFALEWNGYKVVFGGDTAPNIWYPEYAKGADLAIHECWMTSDQMMTKYNQPAQLALRINLDFHTSAQSFGQIMNMV
QPRHAVAYHFFNDDDTRYDIYTGVRENYAGPLSMATDMMVWNITRDAVTERMAVSPDHAWDVAGPSEDLAPDRNRASEYTQYILDGRLNV
DEANAHWKQEFMGRTGLTTEDLGVGS


>gb|MF445022.1|+|1-1161|PNGM-1 [uncultured bacterium]
ATGGCAGGTGGAAAAGTAACCTCATCAACAGGTATCGCACCCAAACGGTACGTCTATTATCCAGGCAGTGAAGAATTGGGGCCCGATGAG
ATTCGGGTTATTGCTTGTGGCACAGGCATGCCTACGGCGCGTCGTGCTCAAGCAGCGGCCGCCTGGGTGGTAGAGCTAGGCAACGGTGAC
AAATTCATCGTCGACATTGGCAGCGGCTCAATGGCCAACATCCAATCGTTGATGATCCCGGCTAATTATTTGACCAAGATTTTTCTGACG
CATTTGCACACCGACCACTGGGGCGACCTGGTGTCTATGTGGGCAGGCGGTTGGACAGCCGGGCGCACGGATCCGTTAGAGGTATGGGGA
CCAAGCGGTTCACGCGAAGATATGGGCACAAAGTACGCCGTCGAGCACATGCTCAAGGCGTACAATTGGGACTATATGACACGAGCCGTG
ACGATTAATCCCCGCCCCGGAGATATCAATGTTCACGAGTTCGACTATCGTGCCCTCAACGAGGTTGTCTATCAAGAGAACGGCGTCACT
TTCCGCTCCTGGCCCTGTATTCACGCGGGAGACGGACCGGTCAGCTTTGCCCTAGAGTGGAATGGCTACAAGGTGGTTTTTGGCGGAGAC
ACCGCCCCCAATATTTGGTACCCAGAATACGCCAAGGGTGCTGACCTGGCGATCCATGAGTGCTGGATGACCTCCGATCAAATGATGACA
AAATATAACCAGCCGGCACAGCTTGCACTGCGCATCAATCTGGACTTTCACACCTCAGCGCAATCCTTTGGCCAGATTATGAATATGGTG
CAGCCACGCCATGCCGTAGCCTATCACTTTTTCAACGATGATGACACGCGGTACGATATCTATACTGGCGTAAGAGAGAACTATGCCGGT
CCCCTTTCAATGGCTACCGACATGATGGTGTGGAATATCACTCGAGACGCAGTCACCGAGCGTATGGCTGTCTCGCCGGATCATGCGTGG
GATGTGGCAGGTCCTTCCGAAGATCTGGCGCCAGATCGGAATAGAGCCTCGGAGTACACGCAGTATATCCTCGACGGCCGTCTCAATGTC
GACGAGGCCAATGCCCATTGGAAGCAGGAGTTCATGGGTCGTACTGGATTAACGACCGAGGATTTGGGAGTGGGAAGCTAA