Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics

Accession ARO:3004138
CARD Short NameMcat_23S_MAC
DefinitionPoint mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics.
AMR Gene Family23S rRNA with mutation conferring resistance to macrolide antibiotics
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family]
Publications

Liu Y, et al. 2015. Microb. Drug Resist. 21(5):507-11 High-Level Macrolide-Resistant Moraxella catarrhalis and Development of an Allele-Specific PCR Assay for Detection of 23S rRNA Gene A2330T Mutation: A Three-Year Study at a Chinese Tertiary Hospital. (PMID 25923017)

Resistomes

Prevalence of Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: rRNA gene variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: rRNA gene variant model

Model Definition: Ribosomal RNA (rRNA) Gene Variant Models (RVM) are similar to Protein Variant Models (PVM), i.e. detect sequences based on their similarity to a curated reference sequence and secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles, except RVMs are designed to detect AMR acquired via mutation of genes encoding ribosomal RNAs (rRNA). RVMs include a rRNA reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTN bit-score above the curated BLASTN cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTN bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastN): 5000

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:



>gb|CP002005.1|-|317714-320869|Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics [Moraxella catarrhalis BBH18]
ATGGTCAAGCCAAACGAGCAATTAGTATTGGTTAGCTACATGTATCACTACACTTCCACACCCAACCTATCAACGTCGTCGTCTACAACG
GCTCTTTAGGGAAATCTTATCTTGAGGTGGGCTTCCCGCTTAGATGCTTTCAGCGGTTATCCCATCCGAACATAGCTACTCGGCAATGCC
ACTGGCGTGACAACCGAAACACCAGAGGTTCGTCCACTCTGGTCCTCTCGTACTAGGAGCAGATCCTCTCAAATTTCCAACGCCCACGGT
AGATAGGGACCGAACTGTCTCACGACGTTCTAAACCCAGCTCGCGTACCTCTTTAAATGGCGAACAGCCATACCCTTGGGACCTGCTTCA
GCCCCAGGATGAGATGAGCCGACATCGAGGTGCCAAACACCGCCGTCGATATGAACTCTTGGGCGGTATCAGCCTGTTATCCCCAGAGTA
CCTTTTATCCGTTGAGCGATGGCCCTTCCATACAGAACCACCGGATCACTAAGACCTACTTTCGTACCTGCTCGACTTGTGGGTCTCGCA
GTTAAGCGCGCTTTTGCCTTTATACTCTTTGAACGATTTCCGACCGTTCTGAGCGCACCTTCGTACTCCTCCGTTACTCTTTAGGAGGAG
ACCGCCCCAGTCAAACTACCCACCATACATTGTCCTTGGATTTGTTGATCCTAAGTTAGAACCCCAACATAACCAGGGTGGTATTTCAAG
GTTGGCTCCACAAATACTGGCGTATCTGCTTCAAAGCCTCCCACCTATCCTACACAAGTTAGGTCAAAGTTCAATGTAAAGCTGTAGTAA
AGGTTCACGGGGTCTTTCCGTCTAGCCGCGGGTACACAGCATCTTCACTGCGATTTCGATTTCACTGAGTCTCTGCTGGAGACAGCGCTG
CCATCATTATGCCATTCGTGCAGGTCGGAACTTACCCGACAAGGAATTTCGCTACCTTAGGACCGTTATAGTTACGGCCGCCGTTTACTG
GGGCTTCGATCAAGAGCTTCGCTTACGCTAACCCCATCAATTAACCTTCCAGCACCGGGCAGGCATCACACCCTATACGTCCACTTTCGT
GTTTGCAGAGTGCTGTGTTTTTAATAAACAGTTGCAGCAGCCTGGTATCTGCGACTGCCAACAGCTCAAAGAGCAAGTCTTATCACCATC
GGCAGCGTACCTTCTCCCGAAGTTACGGTACCATTTTGCCTAGTTCCTTCAGCAGAGTTCTCTCAAGCGCCTTGGTATTCTCTACCTGAC
CACCTGTGTCGGTTTCGGGTACGATTCGTTTATGACTATCGCTTAGAAGCTTTTCCTGGAAGCAGGGTATTTGCCACTTTGCCAGTAAAC
TGGCTTGCTATCAGATCTCATTAATAACCGAGCGGATTTGCCTACTCAGTCTAACTACATCCTTCCACCTGGACAACCATCGCCAGGCTG
GCATAACCTTCTCCGTCCCTCCATCGCATCATAAACAAGTATCGGAATATTAACCGATTTCCCATCGACTACGCCTTTCGGCCTCGCCTT
AGGGGTCGACTCACCCAGCCCCGATTAACGTTGGACTGGAACCCTTGGTCTTCCGGCGAACGGGCTTTTCACCCGTTTTGTCGTTACTCA
CGTCAGCATTCGCTCTTGTGATACCTCCAGCACACCTTACAGTGCACCTTCACAGGCTTACACAACGCTCCCCTACCACTTAATTGAAAC
AATTAAATCCGCAGCTTCGGCTCCTAGTTTGAGCCCCGTTACATCTTCCGCGCAGGCCGACTCGACTAGTGAGCTATTACGCTTTCTTTA
AAGGGTGGCTGCTTCTAAGCCAACCTCCTAGCTGTCTGTGCCTTCCCACATCGTTTCCCACTTAACTAGGAATTTGGGGCCTTAGCTGGC
GGTCTGGGTTGTTTCCCTCTTGACGACGGACGTTAGCACCCGCCGTCTGTCTCCCGGATATTACTCATCGGTATTCGGAGTTTGCATCGG
TTTGGTAAGTCGGTGTGACCCCCTAGCCGAAACAGTGCTCTACCCCCAATGGTATTCGTCCGAGGCGCTACCTAAATAGCTTTCGGGGAG
AACCAGCTATCACCGAGTTTGATTAGCCTTTCACCCCTATCCACAAGTCATCCCCTGGCTTTTCAACGACAGTGGGTTCGGTCCTCCGGT
GCCTGTTACGGCACTTTCAACCTGCTCATGGATAGATCACTCGGTTTCGGGTCTATACCCTGCAACTCATTCGCCCTATTAAGACTCGGT
TTCCCTACGGCTCCCCTATTCGGTTAACCTTGCTACAGAATATAAGTCGCTGACCCATTATACAAAAGGTACGCCGTCACCCGACCACTT
AATCGTTCTGATTGTCAAATTGTGATTTGACACGATTCATCAAGAAAGTTCTCATACGACCATTATTTTTTATGGTTCGCTCTCGTTTTC
TTGCCACTTGTTCATTAATGTAGGCTTCACAATAAACAATACGCCATGTTCTTGCTCTGGTTGAGTAAGTTGTGCCATTATTATGGTCAT
CAATTCTTTGTTTTAAACTGGTGGTAAAACCAACATAAAACTCATCATGATTATCCACGTTTTGTATGACATAGACGTAGTAAAAATTCA
TTGTTATCCTCAAAACGATTAAGTGGTCGGGCTCCGACTGCTTGTATGCACACGGTTTCAGGTTCTATTTCACTCCCCTAACAGGGGTTC
TTTTCGCCTTTCCCTCACGGTACTGGTTCACTATCGGTCAGTCAGGAGTATTTAGCCTTGGAGGATGGTCCCCCCATCTTCAGACAGAAT
TTCTCGTGTTCCGCCCTACTTAATATGTCGCTTAAACAGTTTCGCATACAGGACTATCACCTACTATGGTTGGCTTTCCCACGCCATTTT
GCTACTGTAAAATTGATCGGCTCCTCCGTGTTCGCTCGCCGCTACTTACGGAATCTCATTTGATGTCTTTTCCTCGGGGTACTGAGATGT
TTCACTTCTCCCGGTTTGCCTTACACAGTAAACTGTGTAATAACCAACTTATGTTGGTTGGGTTTCCCCATTCAGAAATCGCCGGGTCAC
AGGATATTGCCACCTCACCGACGCTTATCGCAGGCTATCACGTCTTTCATCGCCTCTGACTGCCAAGGCATCCACCATGTGCACTTCATT
ACTTGA