Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin

Accession ARO:3004546
DefinitionPoint mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin.
AMR Gene Family23S rRNA with mutation conferring resistance to macrolide antibiotics
Drug Classglycopeptide antibiotic, streptogramin antibiotic, lincosamide antibiotic, macrolide antibiotic, phenicol antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target alteration
Classification48 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ antibiotic mixture
+ glycopeptide antibiotic [Drug Class]
+ mechanism of antibiotic resistance
+ streptogramin antibiotic [Drug Class]
+ antibiotic target alteration [Resistance Mechanism]
+ antibiotic target
+ bleomycin
+ protein synthesis machinery targeted by antibiotic
+ bleomycinic acid [Antibiotic]
+ nucleic acid targeted by antibiotic
+ streptogramin A antibiotic
+ bleomycin A2 [Antibiotic]
+ lincosamide antibiotic [Drug Class]
+ determinant of antibiotic resistance
+ streptogramin B antibiotic
+ bleomycin B2 [Antibiotic]
+ mutation conferring antibiotic resistance
+ macrolide antibiotic [Drug Class]
+ phenicol antibiotic [Drug Class]
+ vernamycin B-gamma [Antibiotic]
+ vernamycin C [Antibiotic]
+ pristinamycin IIA [Antibiotic]
+ ribonucleic acid
+ patricin A [Antibiotic]
+ lincomycin [Antibiotic]
+ thiamphenicol [Antibiotic]
+ azidamfenicol [Antibiotic]
+ pristinamycin IA [Antibiotic]
+ griseoviridin [Antibiotic]
+ clindamycin [Antibiotic]
+ patricin B
+ florfenicol [Antibiotic]
+ ostreogrycin B3 [Antibiotic]
+ virginiamycin S2 [Antibiotic]
+ madumycin II [Antibiotic]
+ quinupristin [Antibiotic]
+ antibiotic resistant gene variant or mutant
+ 50S ribosomal subunit
+ dalfopristin [Antibiotic]
+ pleuromutilin antibiotic [Drug Class]
+ pristinamycin IB [Antibiotic]
+ chloramphenicol [Antibiotic]
+ rRNA with mutation conferring antibiotic resistance
+ antibiotic sensitive peptidyl transferase (23S rRNA)
+ 23S rRNA with mutation conferring antibiotic resistance
+ determinant of macrolide resistance
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug erythromycin [Antibiotic]
+ 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family]
Publications

Vacher S, et al. 2003. Antimicrob. Agents Chemother. 47(3):1125-8 PCR-restriction fragment length polymorphism analysis for detection of point mutations associated with macrolide resistance in Campylobacter spp. (PMID 12604552)

Resistomes

Prevalence of Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: rRNA gene variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Campylobacter coli8.7%0%6.06%
Campylobacter jejuni0.7%0%1.11%
Listeria monocytogenes0%0%0.03%
Show Perfect Only


Detection Models

Model Type: rRNA gene variant model

Model Definition: The rRNA gene variant model is an AMR detection model used to identify ribosomal RNA (rRNA) genes with mutations shown clinically to confer resistance to known antibiotic(s) relative to the wild-type rRNA sequence. Like the protein variant model, rRNA gene variant models detect the presence of an rRNA sequence based on its homolog, and then secondarily search submitted query sequences for a curated mutation. This model includes an rRNA gene reference sequence, a BLASTN bitscore cutoff, and a set of mapped resistance variants. A submitted sequence must have both high homolog to the reference sequence and include a known resistance variant to be detected.

Legend:

  • discovered in clinical, agricultural, or environmental isolates
  • discovered via laboratory selection experiments


Bit-score Cut-off (blastN): 5000

PMID: 12604552A2074C A2075G


>gb|NR_076226.1|+|1-2912|Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin [Campylobacter jejuni subsp. jejuni]
AGCTACTAAGAGCGAATGGTGGATGCCTTGACTGGTAAAGGCGATGAAGGACGTACTAGACTGCGATAAGCTACGGGGAGCTGTCAAGAA
GCTTTGATCCGTAGATTTCCGAATGGGGCAACCCAATGTATAGAGATATACATTACCTATATAGGAGCGAACGAGGGGAATTGAAACATC
TTAGTACCCTCAGGAAAAGAAATCAATAGAGATTGCGTCAGTAGCGGCGAGCGAAAGCGCAAGAGGGCAAACCCAGTGCTTGCACTGGGG
GTTGTAGGACTGCAATGTGCAAGAGCTGAGTTTAGCAGAACATTCTGGAAAGTATAGCCATAGAGGGTGATAGTCCCGTATGCGAAAAAC
AAAGCTTAGCTAGCAGTATCCTGAGTAGGGCGGGACACGAGGAATCCTGTCTGAATCCGGGTCGACCACGATCCAACCCTAAATACTAAT
ACCAGATCGATAGTGCACAAGTACCGTGAGGGAAAGGTGAAAAGAACTGAGGTGATCAGAGTGAAATAGAACCTGAAACCATTTGCTTAC
AATCATTCAGAGCACTATGTAGCAATACAGTGTGATGGACTGCCTTTTGCATAATGAGCCTGCGAGTTGTGGTGTCTGGCAAGGTTAAGC
AAACGCGAAGCCGTAGCGAAAGCGAGTCTGAATAGGGCGCTTAGTCAGATGCTGCAGACCCGAAACGAAGTGATCTATCCATGAGCAAGT
TGAAGCTAGTGTAAGAACTAGTGGAGGACTGAACCCATAGGCGTTGAAAAGCCCCGGGATGACTTGTGGATAGGGGTGAAAGGCCAATCA
AACTTCGTGATAGCTGGTTCTCTCCGAAATATATTTAGGTATAGCGTTGTGTCGTAATATAAGGGGGTAGAGCACTGAATGGGCTAGGGC
ATACACCAATGTACCAAACCCTATCAAACTCCGAATACCTTATATGTAATCACAGCAGTCAGGCGGCGAGTGATAAAATCCGTCGTCAAG
AGGGAAACAACCCAGACTACCAGCTAAGGTCCCTAAATCTTACTTAAGTGGAAAACGATGTGAAGTTACTTAAACAACCAGGAGGTTGGC
TTAGAAGCAGCCATCCTTTAAAGAAAGCGTAATAGCTCACTGGTCTAGTGATTTTGCGCGGAAAATATAACGGGGCTAAAGTAAGTACCG
AAGCTGTAGACTTAGTTTACTAAGTGGTAGGAGAGCGTTCTATTTGCGTCGAAGGTATACCGGTAAGGAGTGCTGGAGCGAATAGAAGTG
AGCATGCAGGCATGAGTAGCGATAATTAATGTGAGAATCATTAACGCCGTAAACCCAAGGTTTCCTACGCGATGCTCGTCATCGTAGGGT
TAGTCGGGTCCTAAGTCGAGTCCGAAAGGGGTAGACGATGGCAAATTGGTTAATATTCCAATACCAACATTAGTGTGCGATGGAAGGACG
CTTAGGGCTAAGGGGGCTAGCGGATGGAAGTGCTAGTCTAAGGTCGTAGGAGGTTATACAGGCAAATCCGTATAACAATACTCCGAGAAC
TGAAAGGCTTTTTGAAGTCTTCGGATGGATAGAAGAACCCCTGATGCCGTCGAGCCAAGAAAAGTTTCTAAGTTTAGCTAATGTTGCCCG
TACCGTAAACCGACACAGGTGGGTGGGATGAGTATTCTAAGGCGCGTGGAAGAACTCTCTTTAAGGAACTCTGCAAAATAGCACCGTATC
TTCGGTATAAGGTGTGGTTAGCTTTGTATTAGGATTTACTCTGAAAGCAAGGAAACTTACAACAAAGAGTCCCTCCCGACTGTTTACCAA
AAACACAGCACTCTGCTAACTCGTAAGAGGATGTATAGGGTGTGACGCCTGCCCGGTGCTCGAAGGTTAATTGATGGGGTTAGCATTAGC
GAAGCTCTTGATCGAAGCCCGAGTAAACGGCGGCCGTAACTATAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGTTAAATACCGACCTG
CATGAATGGCGTAACGAGATGGGAGCTGTCTCAAAGAGGGATCCAGTGAAATTGTAGTGGAGGTGAAAATTCCTCCTACCCGCGGCAAGA
CGGAAAGACCCCGTGGACCTTTACTACAGCTTGACACTGCTACTTGGATAAGAATGTGCAGGATAGGTGGGAGGCTTTGAGTATATGACG
CCAGTTGTATATGAGCCATTGTTGAGATACCACTCTTTCTTATTTGGGTAGCTAACCAGCTTGAGTTATCCTCAAGTGGGACAATGTCTG
GTGGGTAGTTTGACTGGGGCGGTCGCCTCCCAAATAATAACGGAGGCTTACAAAGGTTGGCTCAGAACGGTTGGAAATCGTTCGTAGAGT
ATAAAGGTATAAGCCAGCTTAACTGCAAGACATACAAGTCAAGCAGAGACGAAAGTCGGTCTTAGTGATCCGGTGGTTCTGTGTGGAAGG
GCCATCGCTCAAAGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTCCCCCAAGAGCTCACATCGACGGGGAGGTTTGGCACCTCGAT
GTCGGCTCATCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTATGGCTGTTCGCCATTTAAAGCGGTACGCGAGCTGGGTTCAGAACGTC
GTGAGACAGTTCGGTCCCTATCTGCCGTGGGCGTAAGAAGATTGAAGAGATTTGACCCTAGTACGAGAGGACCGGGTTGAACAAACCACT
GGTGTAGCTGTTGTTCTGCCAAGAGCATCGCAGCGTAGCTAAGTTTGGAAAGGATAAACGCTGAAAGCATCTAAGCGTGAAGCCAACTCT
AAGATGAATCTTCTCTAAGCTCTCTAGAAGACTACTAGTTTGATAGGCTGGGTGTGTAATGGATGAAAGTCCTTTAGCTGACCAGTACTA
ATAGAGCGTTTGGCTTATCTTTAATAAAGCAT