msrF

Accession ARO:3005087
CARD Short NamemsrF
DefinitionmsrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics.
AMR Gene Familymsr-type ABC-F protein
Drug Classstreptogramin antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesMacrococcus canisg
Resistomes with Sequence VariantsMacrococcus canisg+wgs, Staphylococcus aureusg
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ msr-type ABC-F protein [AMR Gene Family]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
Publications

Schwendener S, et al. 2020. Antimicrob. Agents Chemother. 64(5): The Novel Macrolide Resistance Genes mef(D), msr(F), and msr(H) Are Present on Resistance Islands in Macrococcus canis, Macrococcus caseolyticus, and Staphylococcus aureus. (PMID 32122903)

Resistomes

Prevalence of msrF among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Macrococcus canis21.43%0%12.5%0%
Staphylococcus aureus0.09%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 900


>gb|QHW12375.1|+|msrF [Macrococcus canis]
MEQICFELENVEVTFLDKKILEIDRLAVHQFDRIGIVGKNGAGKSTLLKILGGIIKPTRGKVNRYIDYGYFEQVESPKVSMADPRLLGKL
NVKVDSNNLSGGELTRLKIAQLFTDYYESLLIDEPTTHLDQDGISFLIDKLKYYYGALVLISHDRNLLDELVTTIWEIDDGMIKVYSGNY
SEYLRQKKVEREQQAHDFDLYLKEKNRLEKAAKEKMNKAEKIANSSSMSKKESKAKANRMFESKSKGTSQKSLQRAAKAVEKRIEQLEVV
DAPKEIHTIQFHQTHSTPPLHNKFPILGDRLTLQAGDKTLLEETSFQFPLGKTIAITGNNGSGKTTLIHHIIQKGEGITISPKAVIGFYE
QMGYQFNEDKTVLSYMKARSDYDESKIRSVLHAMNFNGNDLKKNVRYLSGGEATRLVLCQLFLGRYNILILDEPTNFLDIFCIEALERFI
EEYEGTIILISHDKKFVDHVSDTIYKIENKKLNLVN


>gb|MN728682.1|+|17387-18847|msrF [Macrococcus canis]
ATGGAACAAATATGTTTTGAATTAGAAAATGTTGAAGTAACTTTTTTAGATAAAAAAATATTGGAGATTGATCGCTTAGCTGTTCATCAG
TTTGATCGAATAGGTATTGTTGGAAAAAATGGGGCAGGAAAAAGTACATTATTGAAAATACTTGGTGGTATTATTAAGCCTACTAGAGGA
AAAGTAAATCGTTATATAGATTACGGATATTTTGAACAAGTAGAAAGTCCTAAAGTCAGTATGGCTGATCCACGCTTATTAGGAAAATTA
AATGTAAAAGTAGATTCAAATAATCTAAGTGGTGGTGAACTAACAAGACTGAAAATTGCTCAATTATTTACAGACTATTATGAATCGTTG
TTAATTGATGAGCCTACGACACATTTAGATCAAGATGGAATTTCATTTCTCATAGATAAATTAAAGTATTATTATGGTGCATTAGTTTTA
ATCAGTCATGACCGCAATCTACTAGATGAACTCGTTACTACTATATGGGAAATTGATGATGGTATGATTAAAGTATATTCTGGAAATTAC
AGTGAGTATTTGAGACAGAAGAAGGTGGAAAGAGAGCAACAAGCGCATGATTTCGATCTATATTTGAAAGAAAAGAATAGGCTTGAAAAA
GCAGCTAAGGAAAAAATGAATAAAGCTGAAAAAATTGCCAATTCGTCTTCAATGTCAAAGAAAGAATCCAAAGCAAAGGCAAACCGTATG
TTTGAATCAAAATCAAAAGGTACAAGTCAGAAATCACTACAACGAGCTGCAAAAGCTGTTGAAAAAAGAATAGAGCAACTTGAAGTAGTG
GATGCACCTAAAGAAATTCACACAATTCAATTTCATCAGACTCACTCCACACCACCATTACACAACAAGTTTCCAATATTGGGAGATCGT
TTAACTCTACAAGCAGGGGATAAAACACTCTTAGAAGAAACGAGTTTTCAATTTCCATTAGGAAAAACTATAGCAATTACAGGTAATAAT
GGTTCTGGTAAAACGACATTGATTCATCATATTATTCAAAAGGGTGAAGGTATTACTATATCTCCTAAAGCTGTGATTGGATTTTATGAA
CAAATGGGATATCAGTTCAATGAAGATAAAACTGTATTATCTTATATGAAAGCTAGAAGTGATTATGATGAAAGTAAAATACGTTCAGTT
TTACACGCTATGAATTTCAATGGTAATGACTTGAAAAAGAATGTACGATATTTAAGTGGAGGAGAAGCAACTCGATTAGTATTATGTCAG
CTTTTTTTAGGAAGATATAATATTTTGATTCTAGATGAGCCAACAAACTTTTTAGACATTTTTTGTATAGAAGCATTAGAGAGATTTATA
GAAGAATATGAAGGGACTATTATTCTTATTTCGCATGATAAGAAGTTTGTAGATCATGTATCTGATACTATTTATAAAATAGAAAATAAA
AAGTTGAATTTGGTAAATTAA