Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics

Accession ARO:3004161
CARD Short NameProp_23S_MAC
DefinitionPoint mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides.
AMR Gene Family23S rRNA with mutation conferring resistance to macrolide antibiotics
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsPropionibacterium freudenreichiig+wgs+gi
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family]
Publications

Ross JI, et al. 1997. Antimicrob. Agents Chemother. 41(5):1162-5 Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA. (PMID 9145890)

Resistomes

Prevalence of Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: rRNA gene variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Propionibacterium freudenreichii92.59%0%97.44%85.71%
Show Perfect Only


Detection Models

Model Type: rRNA gene variant model

Model Definition: Ribosomal RNA (rRNA) Gene Variant Models (RVM) are similar to Protein Variant Models (PVM), i.e. detect sequences based on their similarity to a curated reference sequence and secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles, except RVMs are designed to detect AMR acquired via mutation of genes encoding ribosomal RNAs (rRNA). RVMs include a rRNA reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTN bit-score above the curated BLASTN cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTN bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastN): 5000

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

PMID: 9145890G2281A G2294A G2295A


>gb|Y10819.1|+|1850-4984|Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics [Propionibacterium freudenreichii]
GTGACAAGCTACTAAGTGCGATCGGTGGATGCCTAGGCACCAAGAGCCGATGAAGGACGTTGTAACCTGCGATAAGCCCTGGGGAGCTGG
TAAACGAGCTTTGATCCGGGGATGTCCGAATGGGGAAACCTCGAAGGTGACCAGTTTAGCTACTGGCGACCGCCGCCTGAATGTATAGGG
CGGTTGGAGGGAACGTGGGGAAGTGAAACATCTTAGTACCCACAGGAAGAGRAAACAACCGTGAWTCCGTGAATATTGGCGAGCGAAAGC
GGAAGAGGCCAAACCGGAGTGTGTGATAGCCGGCAGGTGTTGCATGTGCGGGGTTGTGGGAAGCGTTTTGACTGAACTGCCGTGAGGTCG
GAGAGTGATAAAGGATTGATGAAGCAGAAGCGTCTGGGAAGGCGCGGCATAGATGGTGATACCCCTGTATGCGTAAGTTGATCTCTCTCT
TAATGTTTTCCCAAGTAGTACGGAACCCCTGAAATYCCGTACGAATCTGGCGGACCACCCGTTAAGCCTAAATACBCCTTGGTGACCGAT
MGCGGACAAGTACCCGTGAGGGAAAGGGTGAAAATGTACCCCCGGGAGGGGAGTGAAATAGTMCCTGAAACCGATCGCATACAATCCGTC
GGAGCCTGCCCTTGTGGTGGGTGACGGCGTGCCTTTTGRAAGAATGAGCCTGCGAGTTAGTGGTGTGTGGCGAGGTTAACCCGTGTGGGG
AAGCCGTAGCGAAAGCGAGTCCGAATAGGGCGTTTGAGTCGCATGCTCTAGACCCGAAGCGGTGTGATCTATCCATGGCCAGGGTGAAGC
GACGGTAAGACGTCGTGGAGGCCCGAACCCACCAGGGTTGCAAACCTGGGGGATGAGCTGTGGATAGGGGTGAAAGGCCAATCAAACACC
GTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCATGTGTTTCTTGTCGGAGGTAGAGCACTGGATGGTCTAGGGGGCTTAC
CAGCTTACCGAAATCAGCCAAACTCCGAATGCCGACAAGTGAGAGCATGGCAGTGAGACGGCGGGGGATAAGCTTCGTCGTCGAGAGGGA
AACAGCCCAGATCATCAGCTAAGGCCCCTAAGTGGTGACTAAGTGGAAAAGGACGTGGAGTTGCGGAGACAACCAGGAGGTTGGCTTGGA
AGCAGCCATCCTTGAAAGAGTGCGTAATAGCTCACTGGTCAAGTGATTCTGCACCGACAATTTAGCGGGGCTCAAGTCATCCGCCGAAGC
TGTGGCATCTACGCGTGTATCCGGCATCCTTTGGGGTGTCCAGGTGCGTGGATGGGTAGGGGAGCGTTGTGTGTGCGTTGAAGCGGCGGG
GTGACCCGGTCGTGGAGTGCACGCAAGTGAGAATGCAGGCATGAGTAGCGTATGACGGGTGAGAAACCCGTCCGCCGAATATCCAAGGGT
TCCAGGGTCAAGCTAATCTGCCCTGGGTGAGTCGGGTCCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGT
ACCGGCGCGAGAACGATCCTGCCGAGGTGAGTGATGCTAAGCATGCAAGGCGGTCGTGGGGGCTTCGGTTCCCTGATCGTTGAGTCTGTA
ACCCGATCTTGTAGTAGGCAAGCTGCGGAGGGACGCAGGAAGGTAGTCTGGCACCGTATTGGTTTGCGGTGTTAAGCCTGTAGGGTGTCT
GGCCAGGTAAATCCGGTCGGACGTGTGCCTGAGAGGTGATGAGTGGTGCCACTTTTGTGGTACGTATCCGGATGATCCTATGCTGCCTAG
AAAATCTTCGTGAGCGAGTTCTCGAGCTGCCCGTACCCCAAACCGACACTGGTGGATAGGTAGAGAATACCAAGGCGATCGAGATAATCA
TGGTGAAGGAACTCGGCAAAATCCTCCCGTAACTTCGGAATAAGGGAGACTGGAGGCGTGACGGCAGTTTACTTGTCGGTGCGTCGATAG
TCGCAGAGAATAGGCCCAAGCGACTGCTTACTAAAAGCACAGGTCCGTGCTAAGTCGAAAGACGATGTATACGGACTGACTCCTGCCCGG
TGCTCKGAAGGTTAAGGGGACGTGTTAGCACTTTTGTGCGAGGCACTGAACTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCC
TAAGGKAGCGAAATTCCTTGTCGGGKAAGTTCCGRCCTGSACGAATGGAGTAACGACTTGGGCGCTGTCTCCACCATGAACTCGGCGAAA
TTGCATTACGAGTAAAGATGCTCGTTACGCGCACAGGGACGGAAAGVNCCCGGGACCTTTACTATAGTTTGGTATTGGTGATCGGTACGA
CTTGTGTAGGATAGGTGGGAGACTTTGAAGCGGTCACGCTAGTGATTGTGGAGTCATTGTTGAAATACCACTCTGGTCGTTCTGGTTATC
TAACCTAGGTCCGTGATCCGGATCAGGGACAGTGCCTGATGGGTAGTTTGACTGGGGCGGTCGCCTCCMAAAAGGTAACGGAGGCGCCCA
AAGGTTCCCTCAGCCTGGTTGGTAATCAGGTGTTGAGTGTAAGTGCACAAGGGAGCTTGACTGTGAGACAGACATGTCGAGCAGGGACGA
AAGTCGGGACTAGTGATCYTCTGGTGGATTGTGGAATCGCCAGAACTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTTCC
CGAGCGCTCACAGCGACGGAATGGNTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGTCGGTCCCAAGGGTTGGGCTGTTC
GCCCATTAAAGCGGCACGCGARGCTGGGGKTAAGAACGTCGTGAGACAGTTCCGGKCCCTATACCGCTGCSCGTMGKATCTTGAGAGGGC
TGTCCTTAGTACGCAAGGACCGGGACGGACCAACCTCTGGTGTGCCAGTTGTTCCACCAGGAGCATGGCTGGTTGGCTACGTTGGGGAGT
GATAACCGCTGAAAGCATCTAAGTGGGAAGCACGCTTCAAGATGAGGGTTCCTGCACAGTTAATGTGGTAAGGCCCCCGGTAGACCACCG
GGTGATAGGTCGGATGTGGAAGCATGGTGACATGTGGAGCTGACCGATACTAAGTGGCCGAGGGCTTGTCCCACA