OprZ

Accession ARO:3004142
CARD Short NameOprZ
DefinitionOprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic, cephalosporin, aminoglycoside antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Sequence VariantsAchromobacter insolitusg+wgs, Achromobacter xylosoxidansg+wgs
Classification15 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Bador J, et al. 2017. Antimicrob. Agents Chemother. : The role of AxyZ transcriptional regulator in the overproduction of AxyXY-OprZ multidrug efflux system in Achromobacter spp. mutants selected by tobramycin. (PMID 28584156)

Resistomes

Prevalence of OprZ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Achromobacter insolitus100%0%78.57%0%
Achromobacter xylosoxidans95.65%0%53.44%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 600


>gb|EGP45230.2|-|OprZ [Achromobacter insuavis AXX-A]
MKPVAMTLLALALSGCSLAPTHERPAAPVPAQYDTPAQPGQAAAPQDWRAYFNDPALQAWIAAALANNRDLRVAALRIEEARALYGVQQS
ERLPAIDASGEFSRGRATEPGQPRTPVSNRYRAAVGITAFELDFFGRVRSLSDAALARYLASEEAHRAATLALVAETATAYFNQRSLAEQ
LRLTDDTLALRETTLKLTQRRYDAGLETAIGLRTAQMLVESSRATRAELTREASLARHALGLLAGDFALPLGVDPTPLESQSLTPLAAGL
PSELLTRRPDLRQAEQALRAANADIGAARAAFFPSVQLTTDIGTTADRFSDLFSGGTGGWSFAPRLTLPIFNAGRNRANLSLAETRKHIA
VAQYEGSIQAAFRDVADALSARDALRDQIEAQRKVRDADRERQRLAERRYARGVANYLEMLEAQRSLFESEQEFIRLQQRRLVNAVDLYK
ALGGWDDGSSPAS


>gb|AFRQ01000061.1|-|22599-23990|OprZ [Achromobacter insuavis AXX-A]
ATGAAACCCGTGGCAATGACCCTGCTGGCGCTGGCATTGTCCGGCTGCTCGCTGGCGCCCACCCATGAGCGCCCCGCGGCGCCGGTGCCG
GCGCAGTACGACACGCCGGCGCAGCCCGGCCAGGCCGCCGCGCCGCAGGACTGGCGCGCCTATTTCAACGATCCGGCGCTGCAGGCCTGG
ATCGCGGCCGCGCTGGCCAACAACCGCGACCTGCGCGTGGCGGCGCTGCGCATCGAGGAAGCGCGCGCGCTGTACGGCGTGCAGCAATCC
GAACGCCTGCCGGCCATCGACGCCAGCGGCGAATTCAGCCGCGGCCGCGCGACCGAGCCGGGCCAGCCGCGCACGCCGGTGTCCAACCGC
TACCGCGCGGCCGTCGGCATCACCGCGTTCGAGCTGGACTTCTTCGGCCGGGTGCGGAGCCTGTCGGACGCCGCGCTGGCGCGCTACCTG
GCCAGCGAGGAAGCGCACCGCGCCGCCACGCTGGCGCTGGTGGCGGAGACGGCGACGGCCTACTTCAACCAGCGTTCGCTGGCCGAGCAA
CTGCGCCTGACCGACGACACGCTGGCGCTGCGCGAGACCACGCTCAAGCTGACCCAGCGCCGCTACGACGCCGGGCTGGAAACCGCCATC
GGCCTGCGCACCGCGCAGATGCTGGTGGAAAGCTCGCGCGCCACGCGCGCCGAGCTGACCCGCGAGGCCAGCCTGGCGCGGCACGCGCTG
GGCCTGCTGGCCGGCGATTTCGCGCTGCCGCTCGGCGTCGACCCTACGCCGCTGGAAAGCCAGAGCCTGACGCCGCTGGCGGCGGGGCTG
CCGTCCGAACTGCTGACGCGCCGCCCCGACCTGCGCCAGGCAGAGCAGGCGCTGCGCGCGGCCAACGCCGACATCGGCGCGGCGCGCGCG
GCGTTCTTCCCGTCGGTGCAGCTGACCACGGACATCGGCACCACCGCCGACCGCTTCTCGGATCTGTTCAGCGGCGGCACCGGCGGCTGG
AGCTTCGCGCCGCGCCTGACGCTGCCGATCTTCAACGCCGGCCGCAACCGCGCCAACCTGTCGCTGGCCGAGACCCGCAAGCACATCGCG
GTGGCCCAGTACGAAGGCAGCATCCAGGCCGCGTTCCGCGACGTGGCCGACGCGCTGTCGGCGCGCGACGCGCTGCGCGACCAGATCGAG
GCCCAGCGCAAGGTGCGCGACGCCGACCGCGAACGCCAGCGGCTGGCCGAGCGGCGTTATGCGCGCGGGGTGGCGAACTACCTGGAGATG
CTGGAGGCCCAGCGCAGCCTGTTCGAGTCGGAACAGGAATTCATCCGGCTGCAGCAGCGCCGGCTGGTCAACGCGGTGGATCTGTACAAG
GCGCTGGGCGGCTGGGACGACGGCTCATCGCCGGCGTCCTGA