ANT(2'') [AMR Gene Family]

Accession ARO:3004276
DefinitionA category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ aminoglycoside nucleotidyltransferase (ANT)
1 ontology terms | Show

Cox G, et al. 2015. MBio 6(1): Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia. (PMID 25564464)