AAC(2') [AMR Gene Family]

Accession ARO:3000341
DefinitionA category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside acetyltransferase (AAC)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
3 ontology terms | Show

Rather PN, et al. 1993. J Bacteriol 175(20): 6492-6498. Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii. (PMID 8407825)

Adams MD, et al. 2008. J Bacteriol 190(24): 8053-8064. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. (PMID 18931120)

Ainsa JA, et al. 1997. Mol Microbiol 24(2): 431-441. Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2')-Ic gene from Mycobacterium tuberculosis and the aac(2')-Id gene from Mycobacterium smegmatis. (PMID 9159528)