multidrug resistant Rv1258c [AMR Gene Family]

Accession ARO:3007184
DefinitionMutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics.
Drug Classpolyamine antibiotic, aminoglycoside antibiotic, pyrazine antibiotic, isoniazid-like antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ antibiotic resistant Rv1258c
+ confers_resistance_to_drug_class polyamine antibiotic [Drug Class]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_drug_class pyrazine antibiotic [Drug Class]
+ confers_resistance_to_drug_class isoniazid-like antibiotic [Drug Class]
2 ontology terms | Show

Liu J, et al. 2019. Front Microbiol 10:216 Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis. (PMID 30837962)

Jia H, et al. 2022. Tuberculosis (Edinb) 133:102172 Rv1258c acts as a drug efflux pump and growth controlling factor in Mycobacterium tuberculosis. (PMID 35158297)