mexX

Accession ARO:3003034
Synonym(s)amrA mexG
DefinitionMexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, acridine dye, carbapenem, aminoglycoside antibiotic, diaminopyrimidine antibiotic, fluoroquinolone antibiotic, penam, macrolide antibiotic, antibacterial free fatty acids, monobactam, triclosan, glycylcycline, aminocoumarin antibiotic, cephamycin, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification39 ontology terms | Show
Parent Term(s)3 ontology terms | Show
Publications

Mine T, et al. 1999. Antimicrob Agents Chemother 43(2): 415-417. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa. (PMID 9925549)

Resistomes

Prevalence of mexX among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 730


>gb|BAA34299.1|+|mexX [Pseudomonas aeruginosa PAO1]
MDRLAARLLAALVALFLLGCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLF
QIDPAPLKAALDISRGALPGRGQPRAAADKLKAYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRAR
RALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAAKSRHAAGDPRRPGEGCRRQGHRRAPGPGRRQRVPLAGELLFIDLAVDPGTDTIA
MRALFRNPHRELLPGGYVQVRLQRAVNPQAITVPDALIRTAQSAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQH
AAGSSVQAVVRQPASADAPSPLAASPAGQ


>gb|AB015853|+|146-1315|mexX [Pseudomonas aeruginosa PAO1]
ATGGACCGGCTCGCTGCGCGGCTGCTGGCGGCCCTGGTCGCCCTATTCCTGCTGGGCTGCGAAGAAGCAGCGGACGCCGGGAAGACTGCG
GAGGCCCCCGCCGAGGTCGGCGTGATCGTCGCCAGGCCGGCGCCTATCGGCATCACCAGCGAGCTGCCCGGACGCCTGGAAGCGTACCGC
CAGGCTGAAGTGCGGGCGCGCGTCGCCGGCATCGTCACCCGTCGCCTGTACGAGGAAGGCCAGGACGTCCGCGCCGGCACCGTGCTGTTC
CAGATCGACCCTGCGCCCTTGAAGGCGGCCCTGGACATCAGCCGCGGCGCCCTGCCCGGCCGAGGCCAGCCACGCGCGGCGGCCGACAAG
CTCAAGGCGTACGCCGACCTGATCAAGGACCGCGCCATCAGCGAACGCGAGTACACCGAAGCGCAGACCGACGCGCGCCAGGCCCTGGCG
CAGATCGCCTCGGCCAAGGCCGAACTGGAGCAGGCCCGCCTGCGCCTGGGCTACGCCACGGTCACCGCGCCGATCGACGGCCGCGCGCGG
CGTGCGCTGGTCACCGAAGGCGCGCTGGTCGGCGAGGACTCGCCGACACCGCTGACCCGCGTCGAGCAGATCGATCCGATCTACGTGAAC
TTCTCCCAGCCGGCCGCGAAGTCGCGCCATGCAGCGGGCGATCCGCGAAGGCCAGGTGAAGGGTGTCGCCGACAAGGACATCGCCGTGCG
CCTGGTCCTGGCCGACGGCAGCGAGTACCGCTGGCCGGCGAGCTGCTGTTCATCGACCTGGCGGTCGACCCCGGCACCGACACCATCGCC
ATGCGTGCCCTGTTCCGCAATCCGCATCGCGAATTGCTGCCCGGCGGCTACGTGCAGGTGCGCCTGCAGCGCGCGGTGAACCCGCAGGCG
ATCACCGTCCCGGACGCGCTGATCCGTACCGCCCAGTCCGCCGTGGTCAAGGTGGTCAACCCAAAGGGCTTGGTGGAAGACGTGGAGGTC
CGCGCCGACACCCTGCAGGGCCGCGACTGGATCATCAGCCGCGGGCTCAAGGGCGGCGAGTGGGTGATCGTCGAGAACGCCGCCCAGCAT
GCCGCCGGCTCCAGCGTCCAGGCGGTGGTCCGCCAGCCGGCCAGCGCCGACGCCCCCTCACCGCTGGCCGCCTCGCCGGCGGGCCAGTGA