| Ontology | CARD's Antibiotic Resistance Ontology | ||||||||||
| Accession | ARO:3003709 | ||||||||||
| CARD Short Name | MexZ | ||||||||||
| Definition | MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. | ||||||||||
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump, antibiotic efflux regulatory protein | ||||||||||
| Drug Class | aminoglycoside antibiotic, disinfecting agents and antiseptics, phenicol antibiotic, tetracycline antibiotic, carbapenem, fluoroquinolone antibiotic, macrolide antibiotic, penicillin beta-lactam, cephalosporin | ||||||||||
| Resistance Mechanism | antibiotic efflux | ||||||||||
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance | ||||||||||
| Efflux Regulator | protein(s) or two-component regulatory system modulating antibiotic efflux | ||||||||||
| CARD:Epi text mining of PubMed up to 2021 (top ten associations if supported by more than one publication) |
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| Classification | 32 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic mixture + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + disinfecting agents and antiseptics [Drug Class] + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + carbapenem [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + ofloxacin [Antibiotic] + norfloxacin [Antibiotic] + arbekacin [Antibiotic] + protein(s) or two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + chloramphenicol [Antibiotic] + penicillin beta-lactam [Drug Class] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + meropenem [Antibiotic] + tobramycin [Antibiotic] + tetracycline [Antibiotic] + acriflavine [Antibiotic] + ciprofloxacin [Antibiotic] + cephalosporin [Drug Class] + gentamicin C [Antibiotic] + amikacin [Antibiotic] + erythromycin [Antibiotic] | ||||||||||
| Parent Term(s) | 3 ontology terms | Show + regulates MexXY-OprM + regulates MexXY-OprA + antibiotic efflux regulatory protein [AMR Gene Family] | ||||||||||
| Resistomes with Sequence Variants | Pseudomonas aeruginosag+wgs | ||||||||||
| Publications | Matsuo Y, et al. 2004. FEMS Microbiol. Lett. 238(1):23-8 MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA. (PMID 15336398) |
Prevalence of MexZ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Pseudomonas aeruginosa | 77.91% | 0% | 80.79% | 0% | 0% |
Model Type: protein overexpression model
Model Definition: Protein Overexpression Models (POM) are similar to Protein Variant Models (PVM) in that they include a protein reference sequence, a curated BLASTP bitscore cut-off, and mapped resistance variants. Whereas PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, reporting only those with curated mutations conferring AMR, POMs are restricted to regulatory proteins and report both wild-type sequences and/or sequences with mutations leading to overexpression of efflux complexes. The former lead to efflux of antibiotics at basal levels, while the latter can confer clinical resistance. POMs include a protein reference sequence (often from wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Perfect RGI match is 100% identical to the wild-type reference protein sequence along its entire length, a Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value may or may not contain at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off may or may not contain at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 390
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).| Mutation | Mutation type | PubMed |
|---|---|---|
| Q10Z | single resistance variant | PMID:15336398 |
| V44A | single resistance variant | PMID:15336398 |
| G46S | single resistance variant | PMID:15336398 |
| G195E | single resistance variant | PMID:15336398 |
| Curator | Description | Most Recent Edit |
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