Morganella morganii gyrB conferring resistance to fluoroquinolones

Accession ARO:3003306
CARD Short NameMmor_gyrB_FLO
DefinitionPoint mutation in Morganella morganii resulting in fluoroquinolone resistance.
AMR Gene Familyfluoroquinolone resistant gyrB
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsCitrobacter amalonaticusg, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colig+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogeneswgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaewgs, Morganella morganiig+wgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Shigella boydiiwgs
Classification11 ontology terms | Show
Parent Term(s)14 ontology terms | Show
+ fluoroquinolone resistant gyrB [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic enoxacin [Antibiotic]
+ confers_resistance_to_antibiotic gatifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic grepafloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic lomefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic ofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic pefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic sparfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic trovafloxacin [Antibiotic]
Publications

Nasri Yaiche M, et al. 2014. Ann Clin Microbiol Antimicrob 13: 34. Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene. (PMID 25106550)

Resistomes

Prevalence of Morganella morganii gyrB conferring resistance to fluoroquinolones among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter amalonaticus9.09%0%0%0%
Citrobacter freundii0%0%0.39%0%
Citrobacter portucalensis0%0%0.9%0%
Enterobacter cloacae0%0%0.32%0%
Enterobacter hormaechei0%0%0.04%0%
Enterobacter kobei0%0%0.87%0%
Escherichia coli0.02%0%0.14%0%
Escherichia marmotae100%0%70.83%0%
Klebsiella aerogenes0%0%0.56%0%
Klebsiella huaxiensis100%0%66.67%0%
Klebsiella michiganensis100%0%68.88%0%
Klebsiella oxytoca100%0%73.11%0%
Klebsiella pneumoniae0%0%0.03%0%
Morganella morganii100%0%56.44%0%
Proteus columbae100%0%100%0%
Proteus mirabilis100%0%42.74%0%
Proteus penneri100%0%100%0%
Proteus vulgaris90.91%0%88.89%0%
Shigella boydii0%0%1.11%0%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1200

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

PMID: 25106550S463A S464Y

>gb|AGG29535.1|-|Morganella morganii gyrB conferring resistance to fluoroquinolones [Morganella morganii subsp. morganii KT]
MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDII
VTIHNDNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSEKLELVIRRDGKVHEQIYRHGEPQDRLTVVGETDKTGTRVRFWPSMDTFKGET
EFQYDILAKRLRELSFLNSGVSIRLIDKRDGKEDHFHYEGGIKAFVEYLSRAKTSIHNNV
FYFSTEKDDIGVEISMQWNDSFQENVYCFTNNIPQRDGGAHLAGFRAAMTRTLNSYIEKE
GLNKKSKVSTTGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLSEY
LDENPNDTKIIVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPAFSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLASQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGYVYIAQPPLYKVKKG
KQEQYIKDDEAMEQYQVSIALDGAALYVNENAAPIQGEHLEKLLHEYNGAHKIIRRLERL
YPLALLNSLVYQPKLEESALLNKTEVEAWAQSLTERLTRHEEHGSTYSYRIAENKERQLF
EPVLTIRTHGVDTDYNLDFDFVHGSEYARISKLGELIRGLIEEGAYVVRGERRQNVSNFE
QALDWLMKESRRGLAVQRYKGLGEMNPEQLWETTMNPETRRMLQVTVKDAIATDQLFTTL
MGDDVEPRRAFIEENALKAANIDV



>gb|CP004345.1|-|545200-547614|Morganella morganii gyrB conferring resistance to fluoroquinolones [Morganella morganii subsp. morganii KT]
ATGTCGAATACCTATGACTCCTCAAGTATCAAAGTATTAAAAGGGCTGGACGCGGTGCGTAAACGCCCGGGAATGTACATTGGTGATACC
GATGACGGAACCGGTTTACACCACATGGTCTTCGAGGTTGTTGACAACGCTATCGACGAAGCCCTCGCCGGTTACTGTAAAGACATCATT
GTGACCATTCACAATGATAATTCAGTCTCCGTACAGGATGACGGTCGCGGTATCCCGACCGGGATCCATGAAGAAGAAGGCGTCTCCGCC
GCAGAAGTTATCATGACTGTTCTGCACGCCGGCGGGAAGTTCGATGATAACTCCTATAAAGTCTCAGGCGGCCTGCACGGCGTCGGGGTC
TCTGTTGTTAACGCCCTGTCTGAAAAACTGGAACTGGTTATCCGCCGTGACGGCAAAGTTCACGAGCAGATTTACCGCCACGGTGAACCG
CAGGATCGCCTGACTGTTGTCGGCGAAACCGATAAAACCGGGACACGCGTGCGTTTCTGGCCGAGCATGGACACCTTCAAAGGCGAGACT
GAATTCCAGTACGACATTCTGGCAAAACGCCTGCGCGAACTCTCCTTCCTGAACTCCGGTGTATCGATCCGTCTGATCGATAAACGCGAC
GGCAAAGAAGATCACTTTCACTACGAAGGCGGTATCAAAGCATTCGTGGAATATTTAAGCCGCGCCAAAACTTCGATTCATAACAACGTT
TTCTATTTCTCCACTGAGAAAGACGATATCGGCGTGGAAATCTCCATGCAGTGGAATGACTCCTTCCAGGAAAACGTATACTGCTTCACC
AACAACATTCCGCAGCGCGACGGTGGTGCTCACCTCGCCGGTTTCCGCGCCGCCATGACCCGTACCCTCAACAGCTATATTGAGAAAGAA
GGGCTGAATAAAAAATCCAAAGTCAGCACCACCGGGGACGATGCCCGTGAAGGACTGGTGGCGGTCATTTCCGTCAAAGTGCCGGATCCG
AAATTCTCCTCCCAGACTAAAGACAAGCTGGTCTCTTCCGAAGTGAAAACGGCGGTTGAAACCCTGATGAACGAAAAGCTGTCTGAATAT
CTGGATGAAAACCCGAACGACACCAAAATCATTGTCGGCAAAATTATTGATGCCGCACGCGCCCGTGAAGCTGCACGCCGTGCCCGTGAA
ATGACCCGCCGTAAAGGCGCGCTGGATTTAGCCGGTCTGCCGGGTAAACTGGCGGATTGTCAGGAACGCGACCCGGCCTTCTCCGAACTG
TACTTAGTGGAAGGGGACTCTGCGGGCGGCTCTGCAAAACAGGGGCGTAACCGTAAGAACCAGGCTATCCTGCCGCTGAAAGGTAAAATC
CTGAACGTTGAGAAGGCGCGTTTTGATAAAATGCTGGCTTCTCAGGAAGTTGCCACCCTGATCACCGCACTCGGCTGCGGTATCGGCCGC
GACGAATACAACCCGGACAAACTGCGCTATCACAGCATCATCATCATGACCGATGCCGACGTCGATGGTTCACACATCCGTACCCTGTTA
CTGACTTTCTTCTACCGTCAGATGCCGGAAATCATTGAGCGCGGTTATGTGTATATCGCACAGCCGCCGCTGTATAAAGTGAAAAAAGGC
AAGCAGGAACAGTATATTAAAGATGACGAAGCGATGGAGCAGTATCAGGTCTCTATCGCACTGGATGGCGCGGCACTGTATGTAAACGAA
AATGCAGCTCCGATTCAGGGCGAACATCTGGAAAAACTGCTGCACGAATACAACGGCGCACACAAAATTATCCGCCGTTTAGAGCGTCTC
TATCCGCTGGCACTGTTAAACAGCCTGGTCTACCAGCCGAAACTGGAAGAATCCGCGCTGCTGAACAAAACCGAGGTGGAAGCCTGGGCA
CAGAGCCTGACAGAGCGCCTGACCCGTCATGAAGAGCACGGCAGCACCTACAGCTACCGTATTGCGGAAAACAAAGAGCGCCAGCTGTTT
GAGCCGGTACTGACTATCCGTACCCACGGTGTGGATACTGACTACAATCTGGATTTCGATTTTGTTCACGGCAGCGAATATGCCCGTATC
TCCAAACTGGGTGAGCTTATCCGTGGTCTGATTGAAGAAGGTGCTTATGTTGTCCGTGGTGAACGCCGTCAGAACGTCAGCAACTTTGAG
CAGGCACTGGACTGGCTGATGAAAGAATCACGCCGTGGTCTGGCTGTACAGCGCTATAAAGGGCTGGGTGAAATGAACCCGGAACAGCTG
TGGGAAACCACAATGAACCCGGAAACCCGCCGTATGTTGCAGGTCACGGTAAAAGATGCGATTGCAACGGATCAGTTATTCACCACACTG
ATGGGTGATGATGTTGAACCGCGCCGTGCCTTTATCGAAGAGAATGCCCTGAAAGCGGCAAACATCGACGTATAA