Morganella morganii gyrB conferring resistance to fluoroquinolone

Accession ARO:3003306
DefinitionPoint mutation in Morganella morganii resulting in fluoroquinolone resistance
AMR Gene Familyfluoroquinolone resistant gyrB
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification12 ontology terms | Show
Parent Term(s)14 ontology terms | Show
+ fluoroquinolone resistant gyrB [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic enoxacin [Antibiotic]
+ confers_resistance_to_antibiotic gatifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic grepafloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic lomefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic ofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic pefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic sparfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic trovafloxacin [Antibiotic]
Publications

Nasri Yaiche M, et al. 2014. Ann Clin Microbiol Antimicrob 13: 34. Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene. (PMID 25106550)

Resistomes

Prevalence of Morganella morganii gyrB conferring resistance to fluoroquinolone among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0%0%
Citrobacter amalonaticus33.33%0%0%
Enterobacter cloacae0%0%0.23%
Enterobacter kobei0%0%3.12%
Escherichia coli0%0%0.13%
Klebsiella oxytoca100%0%84.11%
Klebsiella pneumoniae0%0%0%
Morganella morganii100%0%100%
Proteus mirabilis100%0%95.69%
Proteus penneri0%0%100%
Proteus vulgaris66.67%0%100%
Salmonella enterica0%0%0.05%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.

Legend:

  • discovered in clinical, agricultural, or environmental isolates
  • discovered via laboratory selection experiments


Bit-score Cut-off (blastP): 1200

PMID: 25106550S463A S464Y

>gb|AGG29535.1|-|Morganella morganii gyrB conferring resistance to fluoroquinolone [Morganella morganii subsp. morganii KT]
MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDII
VTIHNDNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSEKLELVIRRDGKVHEQIYRHGEPQDRLTVVGETDKTGTRVRFWPSMDTFKGET
EFQYDILAKRLRELSFLNSGVSIRLIDKRDGKEDHFHYEGGIKAFVEYLSRAKTSIHNNV
FYFSTEKDDIGVEISMQWNDSFQENVYCFTNNIPQRDGGAHLAGFRAAMTRTLNSYIEKE
GLNKKSKVSTTGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLSEY
LDENPNDTKIIVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPAFSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLASQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGYVYIAQPPLYKVKKG
KQEQYIKDDEAMEQYQVSIALDGAALYVNENAAPIQGEHLEKLLHEYNGAHKIIRRLERL
YPLALLNSLVYQPKLEESALLNKTEVEAWAQSLTERLTRHEEHGSTYSYRIAENKERQLF
EPVLTIRTHGVDTDYNLDFDFVHGSEYARISKLGELIRGLIEEGAYVVRGERRQNVSNFE
QALDWLMKESRRGLAVQRYKGLGEMNPEQLWETTMNPETRRMLQVTVKDAIATDQLFTTL
MGDDVEPRRAFIEENALKAANIDV



>gb|CP004345.1|-|545200-547614|Morganella morganii gyrB conferring resistance to fluoroquinolone [Morganella morganii subsp. morganii KT]
ATGTCGAATACCTATGACTCCTCAAGTATCAAAGTATTAAAAGGGCTGGACGCGGTGCGTAAACGCCCGGGAATGTACATTGGTGATACC
GATGACGGAACCGGTTTACACCACATGGTCTTCGAGGTTGTTGACAACGCTATCGACGAAGCCCTCGCCGGTTACTGTAAAGACATCATT
GTGACCATTCACAATGATAATTCAGTCTCCGTACAGGATGACGGTCGCGGTATCCCGACCGGGATCCATGAAGAAGAAGGCGTCTCCGCC
GCAGAAGTTATCATGACTGTTCTGCACGCCGGCGGGAAGTTCGATGATAACTCCTATAAAGTCTCAGGCGGCCTGCACGGCGTCGGGGTC
TCTGTTGTTAACGCCCTGTCTGAAAAACTGGAACTGGTTATCCGCCGTGACGGCAAAGTTCACGAGCAGATTTACCGCCACGGTGAACCG
CAGGATCGCCTGACTGTTGTCGGCGAAACCGATAAAACCGGGACACGCGTGCGTTTCTGGCCGAGCATGGACACCTTCAAAGGCGAGACT
GAATTCCAGTACGACATTCTGGCAAAACGCCTGCGCGAACTCTCCTTCCTGAACTCCGGTGTATCGATCCGTCTGATCGATAAACGCGAC
GGCAAAGAAGATCACTTTCACTACGAAGGCGGTATCAAAGCATTCGTGGAATATTTAAGCCGCGCCAAAACTTCGATTCATAACAACGTT
TTCTATTTCTCCACTGAGAAAGACGATATCGGCGTGGAAATCTCCATGCAGTGGAATGACTCCTTCCAGGAAAACGTATACTGCTTCACC
AACAACATTCCGCAGCGCGACGGTGGTGCTCACCTCGCCGGTTTCCGCGCCGCCATGACCCGTACCCTCAACAGCTATATTGAGAAAGAA
GGGCTGAATAAAAAATCCAAAGTCAGCACCACCGGGGACGATGCCCGTGAAGGACTGGTGGCGGTCATTTCCGTCAAAGTGCCGGATCCG
AAATTCTCCTCCCAGACTAAAGACAAGCTGGTCTCTTCCGAAGTGAAAACGGCGGTTGAAACCCTGATGAACGAAAAGCTGTCTGAATAT
CTGGATGAAAACCCGAACGACACCAAAATCATTGTCGGCAAAATTATTGATGCCGCACGCGCCCGTGAAGCTGCACGCCGTGCCCGTGAA
ATGACCCGCCGTAAAGGCGCGCTGGATTTAGCCGGTCTGCCGGGTAAACTGGCGGATTGTCAGGAACGCGACCCGGCCTTCTCCGAACTG
TACTTAGTGGAAGGGGACTCTGCGGGCGGCTCTGCAAAACAGGGGCGTAACCGTAAGAACCAGGCTATCCTGCCGCTGAAAGGTAAAATC
CTGAACGTTGAGAAGGCGCGTTTTGATAAAATGCTGGCTTCTCAGGAAGTTGCCACCCTGATCACCGCACTCGGCTGCGGTATCGGCCGC
GACGAATACAACCCGGACAAACTGCGCTATCACAGCATCATCATCATGACCGATGCCGACGTCGATGGTTCACACATCCGTACCCTGTTA
CTGACTTTCTTCTACCGTCAGATGCCGGAAATCATTGAGCGCGGTTATGTGTATATCGCACAGCCGCCGCTGTATAAAGTGAAAAAAGGC
AAGCAGGAACAGTATATTAAAGATGACGAAGCGATGGAGCAGTATCAGGTCTCTATCGCACTGGATGGCGCGGCACTGTATGTAAACGAA
AATGCAGCTCCGATTCAGGGCGAACATCTGGAAAAACTGCTGCACGAATACAACGGCGCACACAAAATTATCCGCCGTTTAGAGCGTCTC
TATCCGCTGGCACTGTTAAACAGCCTGGTCTACCAGCCGAAACTGGAAGAATCCGCGCTGCTGAACAAAACCGAGGTGGAAGCCTGGGCA
CAGAGCCTGACAGAGCGCCTGACCCGTCATGAAGAGCACGGCAGCACCTACAGCTACCGTATTGCGGAAAACAAAGAGCGCCAGCTGTTT
GAGCCGGTACTGACTATCCGTACCCACGGTGTGGATACTGACTACAATCTGGATTTCGATTTTGTTCACGGCAGCGAATATGCCCGTATC
TCCAAACTGGGTGAGCTTATCCGTGGTCTGATTGAAGAAGGTGCTTATGTTGTCCGTGGTGAACGCCGTCAGAACGTCAGCAACTTTGAG
CAGGCACTGGACTGGCTGATGAAAGAATCACGCCGTGGTCTGGCTGTACAGCGCTATAAAGGGCTGGGTGAAATGAACCCGGAACAGCTG
TGGGAAACCACAATGAACCCGGAAACCCGCCGTATGTTGCAGGTCACGGTAAAAGATGCGATTGCAACGGATCAGTTATTCACCACACTG
ATGGGTGATGATGTTGAACCGCGCCGTGCCTTTATCGAAGAGAATGCCCTGAAAGCGGCAAACATCGACGTATAA