fluoroquinolone resistant DNA topoisomerase

Accession ARO:3000452
DefinitionFluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
4 ontology terms | Show
+ fluoroquinolone resistant parC [AMR Gene Family]
+ fluoroquinolone resistant gyrB [AMR Gene Family]
+ fluoroquinolone resistant gyrA [AMR Gene Family]
+ fluoroquinolone resistant parE [AMR Gene Family]

Hooper DC. 1999. Drug Resist Updat 2(1): 38-55. Mechanisms of fluoroquinolone resistance. (PMID 11504468)

Wohlkonig A, et al. 2010. Nat Struct Mol Biol 17(9): 1152-1153. Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance. (PMID 20802486)

Maruri F, et al. 2012. J Antimicrob Chemother 67(4): 819-831. A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system. (PMID 22279180)