fluoroquinolone resistant gyrA [AMR Gene Family]

Accession ARO:3003292
DefinitionDNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit.
Drug Classfluoroquinolone antibiotic, nybomycin
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ antibiotic resistant DNA topoisomerase subunit gyrA
+ fluoroquinolone resistant DNA topoisomerase
+ targeted_by_antibiotic nybomycin [Drug Class]
Sub-Term(s)
16 ontology terms | Show
Publications

Koirala KD, et al. 2012. Antimicrob Agents Chemother 56(5): 2761-2762. Highly Resistant Salmonella enterica Serovar Typhi with a Novel gyrA Mutation Raises Questions about the Long-Term Efficacy of Older Fluoroquinolones for Treating Typhoid Fever. (PMID 22371897)

Oram M and Fisher LM. 1991. Antimicrob Agents Chemother 35(2): 387-389. 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. (PMID 1850972)

Minnick MF, et al. 2002. Antimicrob Agents Chemother 47(1): 383-386. gyrA mutations in ciprofloxacin-resistant Bartonella bacilliformis strains obtained in vitro. (PMID 12499219)

Maruri F, et al. 2012. J Antimicrob Chemother 67(4): 819-831. A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system. (PMID 22279180)

Drlica K and Zhao X. 1997. Microbiol Mol Biol Rev 61(3): 377-392. DNA gyrase, topoisomerase IV, and the 4-quinolones. (PMID 9293187)