Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones

Accession ARO:3003931
CARD Short NameCgin_gyrA_FLO
DefinitionPoint mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance.
AMR Gene Familyfluoroquinolone resistant gyrA
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ fluoroquinolone resistant gyrA [AMR Gene Family]
Publications

Ehrmann E, et al. 2016. Anaerobe 42:50-54 Multidrug-resistant oral Capnocytophaga gingivalis responsible for an acute exacerbation of chronic obstructive pulmonary disease: Case report and literature review. (PMID 27531625)

Resistomes

Prevalence of Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1500

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:


>gb|EEK14408.1|+|Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones [Capnocytophaga gingivalis ATCC 33624]
MVEGEKLIPINIEDQMKTAYIDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGVRSNT
AHKKSARIVGEVLGKYHPHGDSSVYDTMVRMAQWWNMRYMLVDGQGNFGSIDGDSPAAMR
YTEARMRKMAEDMLIDIDKETVDHSLNFDDTLLEPTVLPTRIPNLLVNGSSGIAVGMATN
MPPHNLAEVVDGIIAYLGNQDITIDELMEYIKAPDFPTGGIIYGYDGVREAFKTGRGRVV
IRAKAHFEEVNGRDCIVVTEVPYQVNPETMREQTSNLVKEGKLEGLADIVDQTGKGGMRI
VYELKKDAIPNVVLNNLFKHTALQSSFSVNNIALVNGRPQQLNLKDLIYHFVEHRHDVVY
RRTEYELKKAKERIHILEGFMKVMATEDTMGKAIEIIRFHDKPKEDLMTEFELTEIQAEA
ILALQLRRINKLLILQTKEEYEQLLAQIIDLEDILARKERRTEIIKEELLEIKSKYGDER
RSVIEYAGGDISIEDIIPDDQVVITISNAGYIKRTSVNEYKTQARGGVGQKASATRDKDF
IEHLFIGTNHQYMLFFTEKGKCFWLRVYEIPEGGKNTKGRAIQNLINIEPDDLVKAVICT
HDLKEKDYTNSHYVIMATKKGIIKKTSLEQYSRPRQNGIVAITIKEDDELLEARLTSGNS
QIMLAVKSGKAIRFPEDKVRAVGRSGSGVRGISLDSDKDEVIGMIAIENPLEETVLVVSE
NGYGKRTFIDEPETGEAVYRITNRGGKGVKTISITEKTGNLVAIKSVLEEDDLMIINKSG
MAIRLPVSGLRVMGRATQGVRLINIKGNDSIAAVAKVMKEDEDENTTEEIENPTEE



>gb|ACLQ01000019.1|+|24239-26749|Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones [Capnocytophaga gingivalis ATCC 33624]
ATGGTTGAAGGAGAAAAACTCATTCCTATTAACATAGAAGACCAGATGAAGACAGCCTACATTGACTATTCAATGTCAGTGATTGTCTCA
AGAGCTTTGCCCGATGTACGCGATGGGCTGAAGCCTGTACATCGTCGTGTACTCTTTGGAATGCACGAGCTTGGCGTACGTAGCAACACC
GCTCATAAGAAATCAGCCCGTATCGTAGGGGAAGTACTCGGTAAGTACCATCCACACGGCGATTCTTCCGTATATGACACAATGGTACGT
ATGGCACAATGGTGGAACATGCGCTATATGCTTGTAGATGGGCAAGGTAACTTTGGTTCTATCGATGGAGACTCTCCTGCAGCTATGCGT
TATACCGAGGCGAGAATGAGAAAAATGGCCGAGGATATGCTGATAGATATCGACAAAGAAACAGTAGATCACAGCCTGAACTTTGACGAT
ACCCTACTCGAACCTACTGTATTGCCTACCCGCATCCCTAACCTACTGGTGAATGGGTCTTCGGGTATTGCTGTAGGTATGGCTACCAAT
ATGCCACCTCATAATCTTGCTGAAGTAGTTGATGGTATAATTGCTTATCTTGGCAATCAAGATATTACCATCGATGAACTTATGGAATAT
ATCAAGGCTCCTGACTTCCCTACAGGTGGAATCATCTATGGCTATGATGGAGTAAGAGAAGCCTTCAAGACTGGACGTGGACGTGTAGTA
ATCCGCGCCAAGGCTCATTTTGAAGAAGTTAATGGTCGTGACTGTATTGTCGTAACTGAAGTTCCCTATCAAGTGAACCCAGAGACGATG
CGTGAACAGACTTCGAACCTTGTCAAAGAAGGCAAACTCGAAGGCCTAGCCGATATCGTAGATCAAACAGGTAAAGGAGGAATGCGCATC
GTATATGAACTCAAAAAAGATGCTATTCCCAACGTAGTGCTGAATAACCTCTTCAAACACACAGCATTACAATCCTCCTTCAGTGTCAAT
AATATTGCCTTGGTCAATGGACGCCCTCAGCAACTGAACCTCAAGGACTTAATATATCACTTTGTAGAACATCGCCACGATGTAGTATAC
AGACGTACTGAGTATGAGCTCAAAAAAGCCAAAGAACGTATCCATATCTTGGAAGGGTTCATGAAGGTGATGGCCACAGAAGACACTATG
GGGAAAGCTATTGAAATCATCCGTTTTCATGACAAGCCCAAAGAGGATTTGATGACCGAGTTCGAGCTTACCGAAATACAAGCTGAAGCT
ATCTTAGCCTTACAGCTACGTCGTATCAATAAGCTATTAATCCTTCAAACCAAAGAAGAATATGAGCAATTATTAGCACAAATTATTGAT
TTGGAAGATATCCTTGCTCGCAAAGAACGCCGTACCGAGATTATCAAAGAAGAACTCTTGGAAATAAAATCCAAATATGGAGACGAACGT
CGTTCTGTCATAGAATATGCAGGGGGTGATATCTCCATTGAGGATATTATCCCTGATGATCAAGTGGTTATTACCATTTCCAACGCAGGT
TACATAAAGCGTACTTCTGTCAATGAATACAAAACCCAAGCACGTGGTGGTGTAGGACAAAAAGCCTCTGCTACTCGTGATAAGGACTTC
ATAGAGCATCTGTTCATAGGTACCAACCACCAGTATATGCTGTTCTTTACAGAGAAAGGTAAGTGTTTTTGGCTCAGGGTGTATGAGATT
CCTGAAGGAGGTAAAAATACCAAAGGACGCGCCATACAGAACCTTATCAATATCGAACCCGATGACCTTGTTAAGGCAGTCATCTGTACC
CATGACCTCAAGGAAAAAGACTATACCAATAGTCACTATGTCATCATGGCTACTAAAAAAGGGATTATTAAGAAAACCAGCTTAGAACAA
TATTCACGTCCACGCCAGAATGGTATCGTTGCCATCACTATCAAAGAAGATGATGAGCTATTAGAAGCACGTCTTACCTCTGGCAACAGC
CAAATCATGCTAGCTGTCAAGTCTGGAAAGGCTATTCGCTTCCCAGAGGACAAGGTGAGAGCTGTAGGGCGTAGTGGCTCTGGAGTACGA
GGTATCTCTTTGGATAGTGACAAAGATGAGGTAATCGGAATGATTGCCATAGAAAATCCTCTGGAAGAAACCGTATTGGTAGTTTCCGAG
AATGGTTATGGTAAGCGTACCTTTATCGATGAACCAGAGACAGGAGAAGCAGTATATCGTATTACCAACCGTGGAGGAAAAGGAGTCAAG
ACTATTTCTATCACAGAGAAAACAGGTAATCTGGTAGCAATCAAGTCAGTTTTGGAAGAAGACGATCTGATGATTATCAATAAGTCGGGT
ATGGCTATTCGCCTCCCTGTAAGTGGACTCCGTGTGATGGGACGTGCTACCCAAGGAGTACGCCTTATCAATATCAAAGGAAATGACTCT
ATTGCCGCAGTAGCAAAGGTTATGAAAGAAGATGAGGATGAAAATACTACCGAAGAGATAGAAAACCCAACAGAAGAATAA