nybomycin [Drug Class]

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Accession ARO:3003780
DefinitionA heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA).
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+ fluoroquinolone resistant gyrA [AMR Gene Family] targeted_by_antibiotic

Strelitz F, et al. 1955. Proc. Natl. Acad. Sci. U.S.A. 41(9):620-4 NYBOMYCIN, A NEW ANTIBIOTIC WITH ANTIPHAGE AND ANTIBACTERIAL PROPERTIES. (PMID 16589716)

Hiramatsu K, et al. 2012. Int. J. Antimicrob. Agents 39(6):478-85 Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature. (PMID 22534508)