fluoroquinolone resistant parC [AMR Gene Family]

Accession ARO:3000619
DefinitionParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations.
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
12 ontology terms | Show

Drlica K and Zhao X. 1997. Microbiol Mol Biol Rev 61(3): 377-392. DNA gyrase, topoisomerase IV, and the 4-quinolones. (PMID 9293187)

Tankovic J, et al. 1996. Antimicrob Agents Chemother 40(11): 2505-2510. Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. (PMID 8913454)

Maki T, et al. 2008. J Fish Dis 31(6): 461-468. Drug resistance mechanism of the fish-pathogenic bacterium Lactococcus garvieae. (PMID 18471102)