Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones

Accession ARO:3003925
CARD Short NameHpin_parC_FLO
DefinitionPoint mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance.
AMR Gene Familyfluoroquinolone resistant parC
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ fluoroquinolone resistant parC [AMR Gene Family]
Publications

Faccone D, et al. 2016. Infect. Genet. Evol. 44:507-9 Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones. (PMID 27497656)

Resistomes

Prevalence of Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1400

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:


>gb|WP_041918279.1|+|Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones [Haemophilus parainfluenzae]
MSNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNA
AAKFKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
AMRYTESRLSKISEILLSELGQGTVDFQPNFDGTLEEPQYLPARLPHILLNGTTGIAVGM
ATDIPPHNINEVADAAVMLLDNPKAGLDDVLNIIQGPDFPTEAEIISPKDDIRKMYETGR
GSIKMRATWHKEDGEIIISALPHQSSPSKIIAQIAEQMTAKKLPMVEDIRDEADYENPVR
IVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLQVLIEWLTFRRT
TVTRRLQHRLDKVLARLHILDGLMIAFLNIDEVIEIIRTEDEPKQVLMARFNLSDEQAEA
ILNLRLRHLAKLEEHQLQAEKDKLEEERSNLELILGSERRLNTLIKKEIQEDAKKYASPR
MSQLVEREEAKAISESEMTPAEPVTVILSEMGWVRCAKGHDIDPEGLSYKAGDKYLAHAC
GKSNQPVIFIDSTGRSYALDPLSLPSARSQGEPLTGKLTLPAGATIEQVIMEPEKQELLM
ASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPETLSESTSLLVSLTSAGRMLIFP
VRDLPALSKGKGNKIISIPAANAKARSELLVKLFLISEQASLEFHSGKRKITLKPEDLQK
FRAERGRKGSQLPRGLHSNVDIVVVEPEHNS



>gb|NC_015964.1|+|1905163-1907418|Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones [Haemophilus parainfluenzae]
ATGAGCAATATTAATTACGAAGGCATCGAGCAGATGCCACTTCGCACCTTTACAGAAAAGGCTTACCTTAATTATTCAATGTACGTCATC
ATGGATCGTGCATTGCCTTTTATTGGCGATGGCTTAAAGCCTGTTCAACGTCGTATTGTCTATGCGATGTCTGAACTGGGTTTAAATGCC
GCGGCAAAATTTAAAAAGTCCGCGCGTACCGTCGGTGATGTGTTAGGTAAATTCCATCCACATGGTGACTCTGCTTGTTATGAAGCCATG
GTATTAATGGCTCAGCCTTTTTCTTATCGTTATCCTTTGGTAGATGGGCAAGGAAACTGGGGGGCGCCAGATGATCCTAAATCATTTGCG
GCAATGCGTTATACAGAATCTCGCCTGTCCAAAATCTCTGAAATTTTATTATCTGAATTAGGCCAAGGCACTGTTGATTTCCAACCGAAC
TTTGATGGTACCTTAGAAGAACCTCAATATTTGCCTGCACGTTTGCCTCATATTCTGTTAAACGGCACCACCGGGATTGCCGTCGGGATG
GCAACCGATATTCCACCACATAATATTAATGAAGTGGCGGATGCCGCTGTTATGCTATTAGATAATCCAAAAGCAGGATTAGATGATGTA
CTCAATATCATTCAAGGCCCGGATTTCCCAACTGAAGCGGAAATTATTTCACCAAAAGATGATATTCGCAAAATGTATGAAACCGGTCGT
GGTTCTATCAAAATGCGTGCAACATGGCATAAAGAAGACGGTGAAATCATCATTAGTGCACTTCCTCATCAATCTTCACCATCAAAAATC
ATTGCGCAAATTGCTGAACAAATGACAGCAAAAAAATTGCCAATGGTGGAAGATATTCGTGATGAAGCAGATTATGAAAACCCTGTACGT
ATCGTGCTTGTGCCACGTTCAAATCGTGTTGATACGGATGCCTTAATGGCGCATTTATTTGCGACGACTGATCTCGAAAAAAGCTATCGT
GTAAATATGAATATGATCGGACTTGATCATAAACCAGCCGTAAAAGGCCTACTTCAAGTTCTTATCGAATGGCTGACATTCCGTCGTACT
ACCGTGACACGTCGTTTACAACATCGTTTAGATAAAGTACTCGCTCGTTTGCACATTTTAGATGGTTTGATGATTGCCTTCCTCAATATT
GACGAAGTGATTGAGATTATTCGTACTGAAGATGAACCAAAACAAGTTTTAATGGCTCGCTTTAACTTAAGTGATGAACAGGCAGAAGCC
ATTTTAAACTTACGTTTACGCCATTTGGCCAAATTAGAAGAACATCAATTACAAGCTGAAAAAGATAAACTCGAAGAAGAGCGGTCAAAT
TTAGAGTTAATTTTAGGATCTGAACGTCGCTTAAATACCTTGATCAAAAAAGAAATTCAAGAAGATGCGAAAAAATACGCCAGCCCTAGA
ATGTCTCAATTAGTTGAACGTGAAGAAGCGAAAGCCATTTCTGAAAGTGAAATGACTCCGGCTGAACCCGTTACCGTTATCTTATCTGAA
ATGGGCTGGGTACGCTGTGCAAAAGGTCATGACATTGATCCGGAAGGATTAAGCTATAAAGCAGGCGATAAATATCTGGCTCACGCTTGC
GGTAAAAGTAATCAGCCTGTAATCTTTATTGACAGCACGGGGCGTAGCTATGCTTTAGATCCATTAAGCTTGCCTTCTGCGCGTTCACAA
GGTGAACCACTCACCGGTAAACTGACATTACCGGCCGGTGCGACCATTGAACAGGTTATTATGGAACCTGAAAAACAAGAATTATTGATG
GCATCAGATGCAGGATATGGTTTTATTTGCAAATTTGAAGATTTAATTGCGCGTAATAAAGCAGGAAAAGCCTTGATTTCTTTGCCAGAA
AATGCGAAAGTCTTGAAACCTGAGACACTTTCCGAGTCGACCTCACTTCTTGTGTCCCTCACTTCAGCGGGTCGAATGCTGATTTTTCCG
GTACGGGATTTACCGGCATTATCAAAAGGGAAAGGCAACAAAATCATCAGTATTCCAGCAGCGAATGCAAAAGCGCGGTCAGAATTATTA
GTGAAATTGTTCTTAATTTCAGAGCAAGCTAGCCTTGAGTTCCATTCCGGTAAACGAAAAATCACATTAAAACCGGAAGATCTGCAAAAA
TTCCGAGCGGAACGCGGCAGAAAAGGCTCCCAATTACCACGTGGATTACATAGCAATGTTGATATTGTGGTAGTTGAACCCGAACACAAC
TCATAA