Accession | ARO:3003313 |
Definition | ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. |
Drug Class | fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic resistant gene variant or mutant + antibiotic molecule + antibiotic resistant DNA topoisomerase subunit |
Parent Term(s) | 4 ontology terms | Show + antibiotic resistant DNA topoisomerase subunit parE + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + derives_from fluoroquinolone sensitive parE + fluoroquinolone resistant DNA topoisomerase |
Sub-Term(s) | 4 ontology terms | Show |