| Accession | ARO:3004126 |
| CARD Short Name | Ecol_LamB |
| Definition | LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains. |
| AMR Gene Family | Sugar Porin (SP) |
| Drug Class | tetracycline antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | reduced permeability to antibiotic, resistance by absence |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + resistance by absence [Resistance Mechanism] + protein modulating permeability to antibiotic + tetracycline antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 6 ontology terms | Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic nalidixic acid [Antibiotic] + gene conferring resistance via absence + confers_resistance_to_antibiotic balofloxacin [Antibiotic] + Sugar Porin (SP) [AMR Gene Family] |
| Publications | Lin XM, et al. 2014. J Proteomics 98:244-53 Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli. (PMID 24412198) Makino K, et al. 1999. Genes Genet Syst 74(5): 227-239. Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak. (PMID 10734605) Zhang DF, et al. 2008. Int. J. Antimicrob. Agents 32(4):315-9 Functional characterisation of altered outer membrane proteins for tetracycline resistance in Escherichia coli. (PMID 18620846) |
Prevalence of Escherichia coli LamB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein knockout model
Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.
Bit-score Cut-off (blastP): 850
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded