AcrEF-TolC confers resistance to ciprofloxacin

Accession ARO:3004083
CARD Short NameAcrEF_TolC_CIP
DefinitionAcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin).
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classcephamycin, cephalosporin, fluoroquinolone antibiotic, penam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ AcrEF-TolC
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
5 ontology terms | Show
+ AcrE part_of
+ AcrF part_of
+ TolC part_of
+ AcrS part_of
+ H-NS regulates

Lau SY and Zgurskaya HI. 2005. J Bacteriol 187(22): 7815-7825. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. (PMID 16267305)

Poole K, et al. 2000. Antimicrob. Agents Chemother. 44(9):2233-41 Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. (PMID 10952561)


Prevalence of AcrEF-TolC confers resistance to ciprofloxacin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data

Detection Models

Model Name: AcrEF-TolC confers resistance to ciprofloxacin

Model Description: AcrEF-TolC efflux pump system of E. coli confers resistance to ciprofloxacin and tetracycline.