fleroxacin [Antibiotic]

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Accession ARO:3004013
Synonym(s)Megalocin Quinodis
DefinitionFleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ fluoroquinolone sensitive gyrB targeted_by_antibiotic

L√°znickov√° T, et al. 1990. J Hyg Epidemiol Microbiol Immunol 34(1):77-80 The antimicrobial activity of Fleroxacin RO 23-6240, a third generation fluoroquinolone derivative, tested in vitro. (PMID 2112571)