Finafloxacin [Antibiotic]

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Accession ARO:3004732
DefinitionAn 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show

Lemaire S, et al. 2011. Int. J. Antimicrob. Agents 38(1):52-9 Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila. (PMID 21596526)

Barnes KB, et al. 2017. Antimicrob. Agents Chemother. 61(7): Demonstrating the Protective Efficacy of the Novel Fluoroquinolone Finafloxacin against an Inhalational Exposure to Burkholderia pseudomallei. (PMID 28438936)