Prulifloxacin [Antibiotic]

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Accession ARO:3007022
DefinitionPrulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show

Ozaki M, et al. 1991. Antimicrob Agents Chemother 35(12):2496-9 In vivo evaluation of NM441, a new thiazeto-quinoline derivative. (PMID 1667252)

Tougou K, et al. 1998. Drug Metab Dispos 26(4):355-9 Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent. (PMID 9531524)

She P, et al. 2021. Curr Microbiol 79(1):12 Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. (PMID 34905092)