| Accession | ARO:3000097 |
| Definition | LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams. |
| Drug Class | penam, penem |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + antibiotic molecule + class A beta-lactamase + beta-lactam antibiotic |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class penam [Drug Class] + SHV-LEN beta-lactamase + confers_resistance_to_drug_class penem [Drug Class] |
| Sub-Term(s) | 44 ontology terms | Show + LEN-1 + LEN-2 + LEN-5 + LEN-7 + LEN-8 + LEN-9 + LEN-10 + LEN-11 + LEN-12 + LEN-13 + LEN-16 + LEN-18 + LEN-19 + LEN-20 + LEN-21 + LEN-22 + LEN-23 + LEN-24 + LEN-4 + LEN-17 + LEN-26 + LEN-3 + LEN-6 + LEN-14 + LEN-15 + LEN-25 + LEN-35 + LEN-36 + LEN-37 + LEN-30 + LEN-32 + LEN-34 + LEN-38 + LEN-39 + LEN-40 + LEN-41 + LEN-42 + LEN-43 + LEN-51 + LEN-55 + LEN-58 + LEN-27 + LEN-28 + LEN-31 |
| Publications | Haeggman S, et al. 2004. Antimicrob Agents Chemother 48(7): 2400-2408. Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae. (PMID 15215087) |