LAP beta-lactamase [AMR Gene Family]

Accession ARO:3004824
DefinitionLAP is a Ambler Class A beta-lactamase gene family that confers resistance to quinolones.
Drug Classfluoroquinolone antibiotic, aminoglycoside antibiotic, tetracycline antibiotic, rifamycin antibiotic
Resistance Mechanismantibiotic inactivation
Classification10 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ class A beta-lactamase
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
2 ontology terms | Show

Poirel L, et al. 2006. Antimicrob. Agents Chemother. 50(12):3992-7 Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital. (PMID 16982792)

Poirel L, et al. 2007. Antimicrob. Agents Chemother. 51(2):631-7 Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. (PMID 17116662)