| Accession | ARO:3001208 |
| Definition | In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams. |
| Drug Class | penam |
| Resistance Mechanism | antibiotic target replacement |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + determinant of antibiotic resistance + antibiotic resistance gene cluster, cassette, or operon + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam resistance operon + antibiotic target replacement [Resistance Mechanism] + beta-lactam antibiotic |
| Parent Term(s) | 4 ontology terms | Show + part_of mec operon + beta-lactam resistant penicillin-binding proteins + antibiotic target replacement protein + confers_resistance_to_drug_class penam [Drug Class] |
| Sub-Term(s) | 5 ontology terms | Show |
| Publications | Fuda C, et al. 2004. J Biol Chem 279(39): 40802-40806. The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. (PMID 15226303) Ubukata K, et al. 1989. J Bacteriol 171(5): 2882-2885. Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. (PMID 2708325) Lim D and Strynadka NC. 2002. Nat Struct Biol 9(11): 870-876. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. (PMID 12389036) Hartman BJ and Tomasz A. 1984. J Bacteriol 158(2): 513-516. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. (PMID 6563036) Garcia-Alvarez L, et al. 2011. Lancet Infect Dis 11(8): 595-603. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. (PMID 21641281) Paterson GK, et al. 2012. J Antimicrob Chemother 67(12): 2809-2813. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. (PMID 22941897) |