| Accession | ARO:3001209 |
| Synonym(s) | mecALGA251 |
| CARD Short Name | mecC |
| Definition | A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. |
| AMR Gene Family | methicillin resistant PBP2 |
| Drug Class | penam |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs+gi |
| Resistomes with Sequence Variants | Staphylococcus aureusg+wgs+gi |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + determinant of antibiotic resistance + antibiotic molecule + mechanism of antibiotic resistance + antibiotic resistance gene cluster, cassette, or operon + beta-lactam resistance operon + beta-lactam antibiotic + antibiotic target replacement [Resistance Mechanism] + beta-lactam resistant penicillin-binding proteins + antibiotic target replacement protein + mec operon + penam [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic methicillin [Antibiotic] + methicillin resistant PBP2 [AMR Gene Family] |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Garcia-Alvarez L, et al. 2011. Lancet Infect Dis 11(8): 595-603. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. (PMID 21641281) Harrison EM, et al. 2013. Antimicrob Agents Chemother 57(3): 1524-1528. A Staphylococcus xylosus isolate with a new mecC allotype. (PMID 23274660) Paterson GK, et al. 2012. J Antimicrob Chemother 67(12): 2809-2813. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. (PMID 22941897) Milheiriço C, et al. 2017. Antimicrob. Agents Chemother. 61(3): Full-Genome Sequencing Identifies in the Genetic Background Several Determinants That Modulate the Resistance Phenotype in Methicillin-Resistant Staphylococcus aureus Strains Carrying the Novel mecC Gene. (PMID 28069659) |
Prevalence of mecC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Staphylococcus aureus | 0.26% | 0% | 0.13% | 0.29% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1250