mecC

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3001209
CARD Short NamemecC
DefinitionmecC encodes an alternative PBP2a protein involved in bacterial cell wall formation. These proteins are acquired by lateral gene transfer and commonly associated with methicillin-resistant Staphylococcus aureus (MRSA). These proteins have lower affinity for penicillin-like antibiotics and therefore are able to perform peptidoglycan synthesis in the presence of beta-lactams.
AMR Gene FamilyPBP2-like beta-lactam resistant peptidoglycan transpeptidase
Drug Classpenicillin beta-lactam, cephalosporin, carbapenem, monobactam
Resistance Mechanismantibiotic target replacement
CARD:Epi text mining of PubMed up to 2021

(top ten associations if supported by more than one publication)
NCBI_TAXONStaphylococcus aureus (78), Staphylococcus (6), Staphylococcus sciuri (4), Staphylococcus epidermidis (2), Staphylococcus haemolyticus (2), Staphylococcus saprophyticus (2)
GAZKingdom of Denmark (7), Europe (6), Kingdom of Spain (4), England (4), Sweden (4), Great Britain (2), Austria (2), Brazil (2), Italy (2), Northeastern Region (2)
FOODONBos taurus (14), dairy cow (10), cow milk (liquid) (8), sheep (3), water food product (2)
ENVOfarm (13), hospital (3)
UBERONanimal hemisphere (16), zone of skin (3)
Classification71 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ beta-lactam antibiotic
+ penicillin beta-lactam [Drug Class]
+ cephalosporin [Drug Class]
+ beta-lactamase resistant penicillin
+ beta-lactamase sensitive penicillin
+ penicillin with extended spectrum
+ other cephalosporins and penems
+ fourth-generation cephalosporin [Drug Subclass]
+ third-generation cephalosporin [Drug Subclass]
+ second-generation cephalosporin [Drug Subclass]
+ first-generation cephalosporin [Drug Subclass]
+ antibiotic target
+ carbapenem [Drug Class]
+ monobactam [Drug Class]
+ moxalactam [Antibiotic]
+ loracarbef [Antibiotic]
+ cefradine [Antibiotic]
+ cephapirin [Antibiotic]
+ ceftizoxime [Antibiotic]
+ ceftiofur [Antibiotic]
+ cefprozil [Antibiotic]
+ cefonicid [Antibiotic]
+ cefmetazole [Antibiotic]
+ mecillinam [Antibiotic]
+ cell wall synthesis enzyme targeted by antibiotic
+ cefalotin [Antibiotic]
+ ceftaroline [Antibiotic]
+ cefdinir [Antibiotic]
+ cefditoren [Antibiotic]
+ ceftibuten [Antibiotic]
+ cefpodoxime [Antibiotic]
+ cefixime [Antibiotic]
+ cefotaxime [Antibiotic]
+ cefaclor [Antibiotic]
+ cefotiam [Antibiotic]
+ cefadroxil [Antibiotic]
+ cefalexin [Antibiotic]
+ doripenem [Antibiotic]
+ mezlocillin [Antibiotic]
+ azlocillin [Antibiotic]
+ ampicillin [Antibiotic]
+ flucloxacillin [Antibiotic]
+ dicloxacillin [Antibiotic]
+ propicillin [Antibiotic]
+ phenoxymethylpenicillin [Antibiotic]
+ benzylpenicillin [Antibiotic]
+ aztreonam [Antibiotic]
+ imipenem [Antibiotic]
+ mechanism of antibiotic resistance
+ piperacillin [Antibiotic]
+ meropenem [Antibiotic]
+ ertapenem [Antibiotic]
+ amoxicillin [Antibiotic]
+ cefuroxime [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftobiprole [Antibiotic]
+ ceftazidime [Antibiotic]
+ cefepime [Antibiotic]
+ cefazolin [Antibiotic]
+ oxacillin [Antibiotic]
+ carbenicillin [Antibiotic]
+ methicillin [Antibiotic]
+ cloxacillin [Antibiotic]
+ cefoxitin [Antibiotic]
+ beta-lactam sensitive penicillin-binding protein
+ determinant of antibiotic resistance
+ antibiotic target replacement [Resistance Mechanism]
+ beta-lactam resistant penicillin-binding proteins
+ antibiotic target replacement protein
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic methicillin [Antibiotic]
+ PBP2-like beta-lactam resistant peptidoglycan transpeptidase [AMR Gene Family]
Sub-Term(s)
2 ontology terms | Show
+ mecR1 regulates
+ mecC-type mecI regulates
Resistomes with Perfect MatchesStaphylococcus aureusg+wgs+gi
Resistomes with Sequence VariantsStaphylococcus aureusg+wgs+gi
Publications

Garcia-Alvarez L, et al. 2011. Lancet Infect Dis 11(8): 595-603. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. (PMID 21641281)

Harrison EM, et al. 2013. Antimicrob Agents Chemother 57(3): 1524-1528. A Staphylococcus xylosus isolate with a new mecC allotype. (PMID 23274660)

Paterson GK, et al. 2012. J Antimicrob Chemother 67(12): 2809-2813. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. (PMID 22941897)

Milheiriço C, et al. 2017. Antimicrob. Agents Chemother. 61(3): Full-Genome Sequencing Identifies in the Genetic Background Several Determinants That Modulate the Resistance Phenotype in Methicillin-Resistant Staphylococcus aureus Strains Carrying the Novel mecC Gene. (PMID 28069659)
Resistomes

Prevalence of mecC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Staphylococcus aureus0.26%0%0.13%0.29%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1250


>gb|WP_000725529.1|+|mecC [Staphylococcus aureus]
MKKIYISVLVLLLIMIIITWLFKDDDIEKTISSIEKGNYNEVYKNSSEKSKLAYGEEEIVDRNKKIYKDLSVNNLKITNHEIKKTGKDKK
QVDVKYNIYTKYGTIRRNTQLNFIYEDKHWKLDWRPDVIVPGLKNGQKINIETLKSERGKIKDRNGIELAKTGNTYEIGIVPNKTPKEKY
DDIARDLQIDTKAITNKVNQKWVQPDSFVPIKKINKQDEYIDKLIKSYNLQINTIKSRVYPLNEATVHLLGYVGPINSDELKSKQFRNYS
KNTVIGKKGLERLYDKQLQNTDGFKVSIANTYDNKPLDTLLEKKAENGKDLHLTIDARVQESIYKHMKNDDGSGTALQPKTGEILALVST
PSYDVYPFMNGLSNNDYRKLTNNKKEPLLNKFQITTSPGSTQKILTSIIALKENKLDKNTNFDIYGKGWQKDASWGNYNITRFKVVDGNI
DLKQAIESSDNIFFARIALALGAKKFEQGMQDLGIGENIPSDYPFYKAQISNSNLKNEILLADSGYGQGEILVNPIQILSIYSALENNGN
IQNPHVLRKTKSQIWKKDIIPKKDIDILTNGMERVVNKTHRDDIYKNYARIIGKSGTAELKMNQGETGRQIGWFVSYNKNNPNMLMAINV
KDVQNKGMASYNATISGKVYDDLYDNGKTQFDIDQ


>gb|NG_047955.1|+|101-2098|mecC [Staphylococcus aureus]
ATGAAAAAAATTTATATTAGTGTGCTAGTTCTTTTACTAATTATGATTATAATAACTTGGTTATTCAAAGATGACGATATTGAGAAAACA
ATTAGTTCTATTGAAAAAGGAAACTATAACGAAGTATATAAAAATAGTTCAGAAAAATCTAAACTGGCATATGGAGAAGAAGAAATTGTA
GATAGGAATAAAAAAATTTACAAAGATTTAAGTGTCAATAACTTAAAAATTACTAATCATGAAATTAAAAAAACTGGAAAAGATAAAAAG
CAAGTTGATGTTAAATATAACATATATACAAAATATGGAACTATACGACGTAATACACAATTAAACTTTATTTATGAAGATAAGCATTGG
AAATTAGATTGGAGACCAGACGTAATAGTACCTGGTTTGAAAAATGGACAGAAAATTAATATAGAAACATTAAAATCAGAGCGAGGCAAA
ATAAAAGATAGAAATGGTATAGAATTAGCTAAAACTGGAAATACATATGAAATCGGTATTGTCCCTAACAAAACACCCAAAGAAAAATAT
GATGATATTGCTCGTGACTTACAAATTGATACAAAAGCTATAACCAATAAAGTTAATCAAAAATGGGTTCAGCCAGATTCATTTGTACCA
ATTAAAAAGATAAATAAACAAGATGAATATATAGACAAATTAATTAAATCATACAATTTACAAATAAACACTATAAAAAGCCGTGTTTAT
CCATTGAACGAAGCAACAGTACACCTTTTAGGTTATGTGGGTCCAATTAATTCTGACGAGTTAAAAAGTAAGCAATTTAGAAACTATAGC
AAAAATACTGTTATTGGAAAAAAAGGCTTAGAACGCCTCTATGATAAACAATTGCAAAACACTGATGGTTTTAAGGTATCCATTGCAAAT
ACTTATGACAATAAACCTTTAGACACATTATTGGAGAAAAAGGCTGAAAACGGAAAAGATCTTCATTTAACTATAGATGCTAGAGTACAA
GAAAGTATTTATAAACATATGAAAAATGACGATGGATCTGGTACAGCATTACAACCAAAAACTGGAGAAATTTTAGCTTTGGTAAGTACC
CCATCGTACGATGTTTATCCATTCATGAATGGATTAAGCAATAATGACTACCGTAAATTAACTAACAATAAAAAAGAGCCTTTGCTCAAC
AAATTTCAAATCACTACATCACCAGGTTCAACCCAAAAAATATTAACATCTATTATAGCCTTAAAAGAAAATAAACTAGACAAAAATACT
AATTTTGATATTTATGGTAAGGGTTGGCAAAAAGATGCATCATGGGGTAATTATAATATCACAAGATTTAAAGTAGTAGACGGCAATATC
GATTTAAAGCAAGCAATAGAATCATCAGACAACATATTTTTTGCCCGCATTGCATTAGCATTAGGAGCCAAAAAATTTGAGCAAGGTATG
CAAGATTTGGGAATCGGTGAAAATATCCCGAGTGATTATCCCTTTTATAAAGCACAAATCTCAAATAGTAATTTAAAAAATGAAATATTA
TTAGCAGATTCAGGATATGGCCAAGGCGAGATACTAGTAAACCCTATACAAATTTTATCAATATACAGTGCTTTAGAAAATAACGGAAAT
ATACAAAATCCTCATGTTTTACGTAAAACAAAATCTCAAATATGGAAAAAAGATATTATACCTAAAAAAGACATAGATATATTAACTAAT
GGTATGGAACGTGTAGTTAATAAAACACATAGGGATGATATATACAAAAATTATGCCCGAATTATTGGTAAATCTGGCACAGCAGAATTA
AAAATGAATCAAGGGGAAACTGGAAGACAAATAGGTTGGTTTGTTTCATATAATAAAAATAATCCTAATATGTTAATGGCGATTAATGTT
AAAGACGTTCAAAATAAAGGGATGGCCAGCTATAATGCTACTATATCTGGAAAAGTTTATGATGATTTGTATGATAATGGAAAAACTCAA
TTTGATATAGATCAGTAA

Curator Acknowledgements
Curator Description Most Recent Edit