| Accession | ARO:3000124 |
| CARD Short Name | mecI |
| Definition | mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. |
| AMR Gene Family | methicillin resistant PBP2 |
| Drug Class | penam |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs+gi, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus hominisg+wgs, Staphylococcus lugdunensisg, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs |
| Resistomes with Sequence Variants | Staphylococcus aureusg+wgs+gi, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus hominisg+wgs, Staphylococcus lugdunensisg, Staphylococcus pseudintermediusg+wgs+gi, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + determinant of antibiotic resistance + mechanism of antibiotic resistance + antibiotic resistance gene cluster, cassette, or operon + antibiotic molecule + beta-lactam resistance operon + antibiotic target replacement [Resistance Mechanism] + beta-lactam antibiotic + mec operon + antibiotic target replacement protein + penam [Drug Class] + beta-lactam resistant penicillin-binding proteins + methicillin resistant PBP2 [AMR Gene Family] + methicillin [Antibiotic] |
| Parent Term(s) | 4 ontology terms | Show |
| Publications | Blázquez B, et al. 2014. Biochemistry 53(10):1548-50 Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA). (PMID 24564530) |
Prevalence of mecI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Staphylococcus aureus | 13.68% | 0% | 10.99% | 4.87% |
| Staphylococcus epidermidis | 43.82% | 0% | 15.79% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 1.2% | 0% |
| Staphylococcus hominis | 18.18% | 0% | 20.69% | 0% |
| Staphylococcus lugdunensis | 3.57% | 0% | 0% | 0% |
| Staphylococcus pseudintermedius | 26.53% | 0% | 22.02% | 26.67% |
| Staphylococcus saprophyticus | 0% | 0% | 1.53% | 0% |
| Staphylococcus simulans | 0% | 0% | 1.75% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 200