| Accession | ARO:3000124 |
| CARD Short Name | mecI |
| Definition | mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. |
| AMR Gene Family | methicillin resistant PBP2 |
| Drug Class | penam |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus hominisg+wgs, Staphylococcus lugdunensisg+wgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs |
| Resistomes with Sequence Variants | Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus hominisg+wgs, Staphylococcus lugdunensisg+wgs, Staphylococcus pseudintermediusg+wgs, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + determinant of antibiotic resistance + mechanism of antibiotic resistance + antibiotic molecule + antibiotic resistance gene cluster, cassette, or operon + beta-lactam antibiotic + beta-lactam resistance operon + antibiotic target replacement [Resistance Mechanism] + penam [Drug Class] + mec operon + antibiotic target replacement protein + beta-lactam resistant penicillin-binding proteins + methicillin [Antibiotic] + methicillin resistant PBP2 [AMR Gene Family] |
| Parent Term(s) | 4 ontology terms | Show |
| Publications | Blázquez B, et al. 2014. Biochemistry 53(10):1548-50 Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA). (PMID 24564530) |
Prevalence of mecI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Staphylococcus arlettae | 25% | 0% | 2.5% | 0% |
| Staphylococcus aureus | 11.88% | 0% | 10.45% | 0% |
| Staphylococcus capitis | 42.86% | 0% | 13.07% | 0% |
| Staphylococcus epidermidis | 35.45% | 0% | 14.95% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 1.1% | 0% |
| Staphylococcus hominis | 14.29% | 0% | 17.95% | 0% |
| Staphylococcus lugdunensis | 3.33% | 0% | 1.85% | 0% |
| Staphylococcus pseudintermedius | 24.53% | 0% | 21.96% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 2.26% | 0% |
| Staphylococcus simulans | 0% | 0% | 1.67% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 200