methicillin [Antibiotic]

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Accession ARO:0000015
Synonym(s)Methicillinum Meticilina Meticillinum Dimocillin Metacillin Methycillin meticillin Meticilline Staphcillin
DefinitionDerived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
7 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ mecA confers_resistance_to_antibiotic
+ abcA confers_resistance_to_antibiotic
+ mecD confers_resistance_to_antibiotic
+ MecC-type methicillin resistance repressor MecI confers_resistance_to_antibiotic
+ mecB confers_resistance_to_antibiotic
+ mecC confers_resistance_to_antibiotic

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)

Tipper DJ. 1985. Pharmacol Ther 27(1): 1-35. Mode of action of beta-lactam antibiotics. (PMID 3889939)