| Accession | ARO:3004185 |
| CARD Short Name | mecD |
| Definition | mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources. |
| AMR Gene Family | methicillin resistant PBP2 |
| Drug Class | penam |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Macrococcus canisg+wgs |
| Resistomes with Sequence Variants | Macrococcus canisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + determinant of antibiotic resistance + antibiotic molecule + mechanism of antibiotic resistance + antibiotic resistance gene cluster, cassette, or operon + beta-lactam resistance operon + beta-lactam antibiotic + antibiotic target replacement [Resistance Mechanism] + beta-lactam resistant penicillin-binding proteins + antibiotic target replacement protein + mec operon + penam [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic methicillin [Antibiotic] + methicillin resistant PBP2 [AMR Gene Family] |
| Publications | Schwendener S, et al. 2017. Sci Rep 7:43797 Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources. (PMID 28272476) |
Prevalence of mecD among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Macrococcus canis | 21.43% | 0% | 12.5% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1000
Type of Antibiotic Resistance: Acquired