mecB

Accession ARO:3003440
Synonym(s)PBP2B
DefinitionA foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams.
AMR Gene Familymethicillin resistant PBP2
Drug Classpenam
Resistance Mechanismantibiotic target replacement
Resistomes with Sequence VariantsMacrococcus canisg+gi
Classification12 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ methicillin resistant PBP2 [AMR Gene Family]
Publications

Harrison EM, et al. 2014. J Antimicrob Chemother 69(4): 911-918. A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. (PMID 24302651)

Resistomes

Prevalence of mecB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Macrococcus canis71.43%0%0%100%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1300


>gb|BAI83385.1|+|mecB [Macrococcus caseolyticus]
MKNKALAILIICICLLIAYNFVKKDEVDKIFDAIELRDSEYLNEHATFLSKSLYDKDQRYKRMDKIDASLGIKEVKVSNVRLVQKKKNKR
QYSANLNFRTKYGNFSREGNYSFEKDEITKKWLLDWSPEVIIPGLTDRNQISIETLESFRGKILDRNGIDIAKDGIHYEVGIDIKNLNKK
NKKNISKLLSISESTLNKKLKQTWVKEGVFLPLKSYIELDDELKLGIQKYHLTVNQTKGRVYPLREATVHLLGYVGEINAEELKNKKFKD
YDEHSIVGKSGIELQYDKQLQNKDGYKVVITSDDALNNDEDVLLEKKPKNGQDIILTIDSKVQRSIYSHLKEDNGSGVAMNPKTGELLAL
VSYPAYDPYEFMFGISDENYKKIVNDKKEPLLNKFQTTSSPGSTQKLITSIIGLKNGTIDASTSYNIVTKGWQRNSSWGGYEVTRFEEVN
GDIDLEKAIAHSDNIFFARATLDMGSEKFIKGMKALDIGRNIPSDYYFQKGQIANPESLKNNFKNEILLADSGYGQGEILISPVQILSIY
SSLINEGKMMKPKLFETTKEDIWKNHIISKDDVDILTRSMRKVVTGTHRLDAERNYAQFAGKTGTAELKTSREEGLGAQIGWFVGYDQNN
PNMMLGISVKNVENKGMSSYNARKFAEIMDELYENGTKKYEIDR


>gb|AB498758|+|3739-5762|mecB [Macrococcus caseolyticus]
ATGAAAAATAAAGCTTTAGCAATTTTAATTATATGTATTTGCCTTTTAATAGCATATAATTTTGTGAAAAAAGATGAAGTTGATAAAATA
TTTGATGCTATTGAATTAAGGGATTCGGAATATCTGAATGAACATGCGACATTCTTATCTAAAAGTCTTTACGACAAAGATCAGAGATAT
AAAAGAATGGATAAGATTGATGCTTCTCTTGGTATTAAAGAAGTGAAAGTTAGTAATGTACGACTCGTGCAAAAGAAAAAAAATAAACGT
CAATATAGTGCAAATTTAAATTTTAGAACTAAATATGGTAATTTTTCTAGAGAAGGGAACTATTCTTTTGAAAAGGATGAAATAACAAAA
AAATGGCTTTTGGATTGGTCACCTGAGGTTATAATACCGGGATTGACTGATAGAAATCAAATCAGTATAGAAACCTTGGAATCTTTCAGA
GGGAAAATACTAGACAGAAACGGGATTGATATAGCGAAAGACGGAATTCATTACGAAGTTGGAATAGATATTAAAAATTTAAATAAAAAA
AATAAGAAAAATATTTCAAAATTGTTATCAATAAGTGAATCGACACTAAATAAAAAGTTAAAACAAACATGGGTAAAAGAAGGTGTTTTT
TTACCTTTAAAATCGTACATAGAGTTGGATGATGAACTTAAATTGGGTATCCAAAAATATCATTTGACGGTTAATCAAACAAAAGGTAGG
GTTTATCCATTAAGAGAAGCAACAGTACATCTTTTAGGGTATGTTGGAGAAATTAATGCTGAAGAATTAAAGAATAAAAAGTTTAAGGAT
TATGATGAACACTCAATCGTAGGAAAAAGTGGTATCGAACTACAATATGATAAACAATTGCAAAATAAAGATGGTTATAAAGTTGTCATA
ACTAGTGATGATGCATTAAATAATGATGAAGATGTCTTGTTAGAAAAGAAACCAAAAAATGGACAGGACATTATATTAACAATTGATAGC
AAAGTACAAAGAAGTATATATAGTCATTTAAAAGAAGATAATGGTTCAGGAGTAGCCATGAATCCTAAAACTGGTGAATTATTAGCTTTA
GTTAGTTATCCTGCATATGACCCCTATGAGTTTATGTTCGGCATTTCCGACGAAAACTACAAAAAGATAGTTAATGATAAGAAAGAGCCC
CTGTTAAATAAATTTCAGACAACCTCTTCCCCAGGATCTACTCAGAAATTAATAACATCTATCATAGGTTTGAAAAATGGGACTATAGAC
GCATCAACCAGCTACAACATAGTAACTAAGGGATGGCAGAGAAATTCTTCATGGGGAGGATATGAAGTTACAAGGTTTGAGGAAGTTAAT
GGAGATATTGATTTAGAAAAAGCGATAGCACATTCTGATAATATATTTTTTGCAAGAGCTACCCTCGATATGGGTTCCGAAAAATTTATT
AAGGGCATGAAAGCTTTAGACATTGGGAGAAATATTCCTTCTGATTATTATTTTCAAAAAGGACAAATTGCAAATCCAGAAAGTTTAAAA
AATAATTTTAAAAATGAAATATTACTAGCTGATTCAGGATATGGCCAGGGAGAAATACTTATAAGTCCAGTACAAATATTATCTATTTAT
AGTTCTTTAATTAATGAAGGTAAAATGATGAAACCTAAATTATTTGAAACAACAAAAGAAGATATTTGGAAAAATCATATTATTTCAAAA
GATGACGTAGATATATTAACAAGAAGCATGAGAAAAGTAGTTACTGGGACACATAGATTGGATGCAGAAAGAAATTATGCACAGTTTGCT
GGAAAAACTGGCACTGCAGAATTGAAAACCTCTAGAGAAGAGGGGTTAGGAGCTCAAATCGGTTGGTTTGTTGGATATGATCAAAATAAT
CCCAATATGATGTTAGGTATAAGTGTGAAGAATGTAGAGAATAAAGGTATGTCGAGTTATAATGCAAGAAAGTTTGCCGAGATAATGGAT
GAATTATATGAAAATGGAACGAAAAAATATGAAATAGATAGGTGA