MecC-type methicillin resistance repressor MecI

Accession ARO:3005046
DefinitionThis MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams.
AMR Gene Familymethicillin resistant PBP2
Drug Classpenam
Resistance Mechanismantibiotic target replacement
Resistomes with Perfect MatchesStaphylococcus aureusg+wgs
Resistomes with Sequence VariantsStaphylococcus aureusg+wgs
Classification12 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ methicillin resistant PBP2 [AMR Gene Family]
Publications

Garcia-Alvarez L, et al. 2011. Lancet Infect Dis 11(8): 595-603. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. (PMID 21641281)

Resistomes

Prevalence of MecC-type methicillin resistance repressor MecI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Staphylococcus aureus0.42%0%0.21%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 200


>gb|CCC86797.1|+|MecC-type methicillin resistance repressor MecI [Staphylococcus aureus subsp. aureus LGA251]
MTREGYDISASEWEIMNTIWNKKLISANDVIEIVQKHKEWSPKTIRTLINRLYKKKFIDRTSRNKIFEYFPIVEEKDMKYKTSKVFLDKV
YEGGLNSLVLNFVENEELSEDDIEELKNILNNKY


>gb|FR821779.1|+|39530-39904|MecC-type methicillin resistance repressor MecI [Staphylococcus aureus subsp. aureus LGA251]
ATGACACGTGAAGGCTATGATATATCAGCGTCAGAATGGGAAATAATGAATACGATTTGGAATAAAAAATTAATAAGTGCTAATGACGTT
ATAGAAATAGTACAAAAGCACAAGGAATGGAGTCCAAAAACAATAAGAACACTAATCAATCGTCTTTACAAAAAGAAATTCATAGATAGA
ACAAGTCGAAATAAAATTTTTGAATATTTCCCAATAGTAGAGGAAAAAGATATGAAGTACAAAACGTCTAAAGTGTTTTTGGATAAAGTG
TATGAAGGTGGATTAAATTCATTAGTCTTAAATTTTGTTGAAAATGAAGAATTGTCCGAAGATGATATTGAAGAATTGAAAAATATATTA
AATAATAAATATTAA