CARB beta-lactamase [AMR Gene Family]

Accession ARO:3000091
DefinitionCARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10.
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class penam [Drug Class]
+ class A beta-lactamase
Sub-Term(s)
22 ontology terms | Show
Publications

Sanschagrin F, et al. 1998. Antimicrob Agents Chemother 42(8): 1966-1972. Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases. (PMID 9687391)

Labia R, et al. 1981. J Antimicrob Chemother 7(1): 49-56. Properties of three carbenicillin-hydrolysing beta-lactamases (CARB) from Pseudomonas aeruginosa: identification of a new enzyme. (PMID 6782068)