| Accession | ARO:3002242 |
| CARD Short Name | CARB-3 |
| Definition | CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. |
| AMR Gene Family | CARB beta-lactamase |
| Drug Class | penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Pseudomonas aeruginosawgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Acinetobacter baumanniig+p+wgs, Acinetobacter indicusg+p, Acinetobacter pittiiwgs, Acinetobacter townerig+gi, Aeromonas hydrophilawgs, Alcaligenes faecalisg, Citrobacter freundiiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colig+p+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs, Laribacter hongkongensiswgs, Morganella morganiig+wgs, Neisseria brasiliensisg+gi, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Pseudomonas stutzeriwgs, Salmonella entericag+wgs+gi, Stenotrophomonas maltophiliawgs, Vibrio choleraeg+wgs+gi, Vibrio fluvialisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + hydrolysis of antibiotic conferring resistance + antibiotic molecule + antibiotic inactivation enzyme + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactam antibiotic + class A beta-lactamase + penam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + CARB beta-lactamase [AMR Gene Family] |
| Publications | Lachapelle J, et al. 1991. Gene 102(1): 7-12. Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 beta-lactamase of Pseudomonas aeruginosa. (PMID 1650733) |
Prevalence of CARB-3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 1.53% | 0% |
| Acinetobacter baumannii | 0.18% | 0.26% | 0.36% | 0% |
| Acinetobacter indicus | 4.76% | 5.66% | 0% | 0% |
| Acinetobacter pittii | 0% | 0% | 0.57% | 0% |
| Acinetobacter towneri | 12.5% | 0% | 0% | 100% |
| Aeromonas hydrophila | 0% | 0% | 0.81% | 0% |
| Alcaligenes faecalis | 5% | 0% | 0% | 0% |
| Citrobacter freundii | 0% | 0% | 1.16% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.96% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.39% | 0% |
| Enterobacter kobei | 0% | 0% | 1.31% | 0% |
| Escherichia coli | 0.02% | 0.08% | 0.17% | 0% |
| Klebsiella michiganensis | 0% | 0.57% | 1.06% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.05% | 0.12% | 0% |
| Laribacter hongkongensis | 0% | 0% | 2.08% | 0% |
| Morganella morganii | 7.69% | 0% | 4.29% | 0% |
| Neisseria brasiliensis | 100% | 0% | 0% | 50% |
| Proteus mirabilis | 4.59% | 0% | 0.83% | 0% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Pseudomonas aeruginosa | 2.76% | 0.29% | 1.31% | 1.39% |
| Pseudomonas monteilii | 0% | 0% | 4.76% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Pseudomonas stutzeri | 0% | 0% | 0.76% | 0% |
| Salmonella enterica | 1.83% | 0% | 3.94% | 3.97% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.45% | 0% |
| Vibrio cholerae | 0.9% | 0% | 1.21% | 4.76% |
| Vibrio fluvialis | 2.63% | 0% | 1.33% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500