| Accession | ARO:3002417 |
| Definition | OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. |
| Drug Class | cephalosporin, penam |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + determinant of antibiotic resistance + beta-lactam antibiotic + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + cephem |
| Parent Term(s) | 3 ontology terms | Show + class A beta-lactamase + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] |
| Sub-Term(s) | 47 ontology terms | Show + OKP-A-1 + OKP-A-2 + OKP-A-3 + OKP-A-4 + OKP-A-5 + OKP-A-6 + OKP-A-7 + OKP-A-8 + OKP-A-9 + OKP-A-10 + OKP-A-11 + OKP-A-12 + OKP-A-13 + OKP-A-14 + OKP-A-15 + OKP-A-16 + OKP-B-1 + OKP-B-2 + OKP-B-3 + OKP-B-4 + OKP-B-5 + OKP-B-6 + OKP-B-7 + OKP-B-8 + OKP-B-9 + OKP-B-10 + OKP-B-11 + OKP-B-12 + OKP-B-13 + OKP-B-14 + OKP-B-17 + OKP-B-18 + OKP-B-19 + OKP-B-20 + OKP-A-17 + OKP-B-16 + OKP-B-21 + OKP-B-22 + OKP-B-23 + OKP-B-24 + OKP-B-34 + OKP-B-36 + OKP-B-40 + OKP-B-41 + OKP-B-45 + OKP-C-1 + OKP-D-1 |
| Publications | Fevre C, et al. 2005. Antimicrob Agents Chemother 49(12): 5149-5152. Variants of the Klebsiella pneumoniae OKP chromosomal beta-lactamase are divided into two main groups, OKP-A and OKP-B. (PMID 16304190) Zou L, et al. 2011. New Microbiol 34(4): 371-378. First detection of OKP-A beta-lactamase in two Serratia marcescens isolates in China. (PMID 22143810) |