OKP beta-lactamase [AMR Gene Family]

Accession ARO:3002417
DefinitionOKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%
Drug Classcephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ class A beta-lactamase
Sub-Term(s)
34 ontology terms | Show
Publications

Fevre C, et al. 2005. Antimicrob Agents Chemother 49(12): 5149-5152. Variants of the Klebsiella pneumoniae OKP chromosomal beta-lactamase are divided into two main groups, OKP-A and OKP-B. (PMID 16304190)

Zou L, et al. 2011. New Microbiol 34(4): 371-378. First detection of OKP-A beta-lactamase in two Serratia marcescens isolates in China. (PMID 22143810)