fosfomycin phosphotransferase

Accession ARO:3000359
DefinitionIn the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic.
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show
+ fosC phosphotransferase family [AMR Gene Family]
+ Fom phosphotransferase family [AMR Gene Family]

Kobayashi S, et al. 2000. Antimicrob Agents Chemother 44(3): 647-650. Characterization of the fomA and fomB gene products from Streptomyces wedmorensis, which confer fosfomycin resistance on Escherichia coli. (PMID 10681332)

Pakhomova S, et al. 2008. J Biol Chem 283(42): 28518-28526. Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. (PMID 18701452)