fosC phosphotransferase family [AMR Gene Family]

Accession ARO:3004245
DefinitionThe fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates.
Drug Classphosphonic acid antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ fosfomycin phosphotransferase
+ confers_resistance_to_drug_class phosphonic acid antibiotic [Drug Class]
2 ontology terms | Show
+ FosC2
+ FosC

Garcia P, et al. 1995. Antimicrob Agents Chemother 39(7): 1569-1573. Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrate. (PMID 7492106)

Wachino J, et al. 2010. Antimicrob Agents Chemother 54(7): 3061-3064. Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. (PMID 20404116)