fosC phosphotransferase family [AMR Gene Family]

Accession ARO:3004245
DefinitionThe fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates.
Drug Classfosfomycin
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class fosfomycin [Drug Class]
+ determinant of fosfomycin resistance
+ fosfomycin phosphotransferase
Sub-Term(s)
2 ontology terms | Show
+ FosC2
+ FosC
Publications

Garcia P, et al. 1995. Antimicrob Agents Chemother 39(7): 1569-1573. Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrate. (PMID 7492106)

Wachino J, et al. 2010. Antimicrob Agents Chemother 54(7): 3061-3064. Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. (PMID 20404116)