streptogramin B biosynthesis

Accession ARO:3000389
DefinitionType B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line.
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Parent Term(s)1 ontology terms | Show

Thibaut D, et al. 1997. J Bacteriol 179(3): 697-704. Purification of peptide synthetases involved in pristinamycin I biosynthesis. (PMID 9006023)

de Crecy-Lagard V, et al. 1997. Antimicrob Agents Chemother 41(9): 1904-1909. Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene. (PMID 9303382)

Aebischer E and Winter-Halder C. 1977. Ann Biol Clin (Paris) 35(3): 255-259. Practical experiment with a Gemsaec analyser for three and half years in a routine laboratory. (PMID 900602)