Accession ARO:3000489
CARD Short Namesav1866
DefinitionSav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classdisinfecting agents and antiseptics
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class]

Dawson RJ and Locher KP. 2007. FEBS Lett 581(5): 935-938. Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP. (PMID 17303126)

Dawson RJ and Locher KP. 2006. Nature 443(7108): 180-185. Structure of a bacterial multidrug ABC transporter. (PMID 16943773)

Private model - RGI is not currently using this model.