| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3001319 |
| Synonym(s) | OPT-80 |
| Definition | A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death. |
| SMILES | CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C |
| PubChem | 10034073 |
| ChEBI | 68590 |
| CAS | 873857-62-6 |
| ChEMBL | CHEMBL1255800 |
| Drug Class | macrocyclic antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + macrocyclic antibiotic [Drug Class] |
| Sub-Term(s) | 1 ontology terms | Show + antibiotic sensitive RNA polymerase switch region targeted_by_antibiotic |
| Publications | Goldstein EJ, et al. 2012. Clin Infect Dis 55(SUPPL 2): S143-S148. Antimicrobial activities of fidaxomicin. (PMID 22752863) Juang P, et al. 2013. J Pharm Pract 26(5): 491-497. Role of fidaxomicin for the treatment of clostridium difficile infection. (PMID 24064437) Louie TJ, et al. 2011. N Engl J Med 364(5): 422-431. Fidaxomicin versus vancomycin for Clostridium difficile infection. (PMID 21288078) Srivastava A, et al. 2011. Curr Opin Microbiol 14(5): 532-543. New target for inhibition of bacterial RNA polymerase: 'switch region'. (PMID 21862392) |
| Curator | Description | Most Recent Edit |
|---|
