fidaxomicin [Antibiotic]

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Accession ARO:3001319
DefinitionA narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death.
Drug Classmacrocyclic antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrocyclic antibiotic [Drug Class]
1 ontology terms | Show

Goldstein EJ, et al. 2012. Clin Infect Dis 55(SUPPL 2): S143-S148. Antimicrobial activities of fidaxomicin. (PMID 22752863)

Juang P, et al. 2013. J Pharm Pract 26(5): 491-497. Role of fidaxomicin for the treatment of clostridium difficile infection. (PMID 24064437)

Louie TJ, et al. 2011. N Engl J Med 364(5): 422-431. Fidaxomicin versus vancomycin for Clostridium difficile infection. (PMID 21288078)

Srivastava A, et al. 2011. Curr Opin Microbiol 14(5): 532-543. New target for inhibition of bacterial RNA polymerase: 'switch region'. (PMID 21862392)