antibiotic sensitive RNA polymerase switch region

Accession ARO:3003439
DefinitionThe switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft.
Drug Classmacrocyclic antibiotic
Classification2 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ nucleic acid synthesis machinery targeted by antibiotic
+ targeted_by_antibiotic fidaxomicin [Antibiotic]
+ targeted_by macrocyclic antibiotic [Drug Class]

Srivastava A, et al. 2011. Curr Opin Microbiol 14(5): 532-543. New target for inhibition of bacterial RNA polymerase: 'switch region'. (PMID 21862392)