frameshift mutation

Accession MO:0000024
DefinitionA frameshift is a type of genetic mutation caused by a nucleotide insertion or deletion ≠ 3 bases. This changes the grouping of codons and thus the reading frame during translation, resulting in a incomplete or inactive protein product. Many frameshift mutations generate downstream STOP codons, resulting in premature peptide translation termination. Frameshifts may also confer antibiotic resistance through partial or total protein loss-of-function. Frameshift mutations are included with relevant models when applicable, with the following notation: [wild-type AA][position]fs;[[wild-type AA][position]STOP], where AA is an amino acid. If the premature STOP codon position is unknown or does not exist, [wild-type AA][position]fs is sufficient. This parameter is currently not included in detection algorithms.
Classification2 ontology terms | Show
Parent Term(s)3 ontology terms | Show