detection model or meta-model

Accession MO:0000001
Synonym(s)
Definition The Comprehensive Antibiotic Resistance Database uses models for the detection of molecular determinants. For example, a "protein homolog" model can contain sequences of antimicrobial resistance genes that do not include mutation as a determinant of resistance, whereas a "protein variant" model will contain reference wild type sequences used for mapping SNPs conferring antimicrobial resistance. The Comprehensive Antibiotic Resistance Database uses meta-models for the detection of combinations of individual molecular determinants. For example, efflux pump systems consist of multiple subunits and regulators that are detected together using the the "efflux pump system" meta-model. In CARD, these models are applied to the detection of antimicrobial resistance elements, but they are broadly applicable to other systems as well, with modifications.
Classification
Parent Term(s) + detection model or parameter (is_a)
Sub-Term(s)
+ protein homolog model (is_a)
+ protein variant model (is_a)
+ rRNA gene variant model (is_a)
+ protein knockout model (is_a)
+ nonfunctional insertion model (is_a)
+ protein overexpression model (is_a)
+ gene cluster meta-model (is_a)
+ efflux pump system meta-model (is_a)
+ protein domain meta-model (is_a)
Publications