| Accession | MO:0000006 | ||
| Definition | Ribosomal RNA (rRNA) Gene Variant Models (RVM) are similar to Protein Variant Models (PVM), i.e. detect sequences based on their similarity to a curated reference sequence and secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles, except RVMs are designed to detect AMR acquired via mutation of genes encoding ribosomal RNAs (rRNA). RVMs include a rRNA reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTN bit-score above the curated BLASTN cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTN bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants. | ||
| Classification | 1 ontology terms | Show | ||
| Parent Term(s) | 1 ontology terms | Show | ||
| Sub-Term(s) | 10 ontology terms | Show + single resistance variant part_of + snp in promoter region part_of + insertion mutation from nucleotide sequence part_of + deletion mutation from nucleotide sequence part_of + high confidence TB + no association with resistance TB + indeterminate confidence TB + moderate confidence TB + minimal confidence TB + BLASTN bit-score | ||
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