moderate confidence TB

Accession MO:0000051
DefinitionThis parameter is part of a confidence model for AMR developed by the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org). The confidence model is based on the likelihood ratio test (LR+) statistic that is used to evaluate whether mutations are positively or negatively associated with phenotypic resistance. The LR+ is derived from a drug susceptibility test, testing sensitivity and specificity. Under the null hypothesis of no association, the LR value is expected to be 1, but deviations from this can be due to an association with resistance or a low number of available isolate samples. The LR+ measures the strength of association between the presence of a mutation and the drug resistance phenotype. A mutation graded as moderate confidence has a moderate association of the mutation with phenotypic drug resistance. Additional data is desirable for improved evidence that the mutation confers or is strongly associated with drug resistance. LR value is greater than 5 but less or equal to 10.
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show